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A pilot comparative study of multi-contrast dental MRI and CBCT: clinical correlates of disease status and inflammatory burden in periodontitis

Aim To evaluate the reliability of multi-contrast dental MRI (dMRI) for periodontal lesion assessment in comparison to cone-beam computed tomography (CBCT). Associations between imaging findings and clinical indicators of periodontal inflammation (i.e., bleeding on probing [BOP], periodontal probing...

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Autori principali: Tekiki, Nouha (Autore) , Lauer, Arne (Autore) , Hartung, Katharina (Autore) , Kirchner, Marietta (Autore) , Schulte, Luisa (Autore) , Li, Hao (Autore) , Jürchott, Alexander (Autore) , Sohani, Meysam (Autore) , Herpel, Christopher (Autore) , Rütters, Maurice (Autore) , Nittka, Mathias (Autore) , Heiland, Sabine (Autore) , Bendszus, Martin (Autore) , Hilgenfeld, Tim (Autore)
Natura: Article (Journal)
Lingua:inglese
Pubblicazione: September 2026
In: Journal of clinical periodontology
Year: 2026, Volume: 53, Fascicolo: 9, Pages: 1382-1392
ISSN:1600-051X
DOI:10.1111/jcpe.70151
Accesso online:Verlag, kostenfrei, Volltext: https://doi.org/10.1111/jcpe.70151
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/jcpe.70151
Testo
Note sull'autore:Nouha Tekiki, Arne Lauer, Katharina Hartung, Marietta Kirchner, Luisa Schulte, Hao Li, Alexander Juerchott, Meysam Sohani, Christopher Herpel, Maurice Ruetters, Mathias Nittka, Sabine Heiland, Martin Bendszus, Tim Hilgenfeld
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Riassunto:Aim To evaluate the reliability of multi-contrast dental MRI (dMRI) for periodontal lesion assessment in comparison to cone-beam computed tomography (CBCT). Associations between imaging findings and clinical indicators of periodontal inflammation (i.e., bleeding on probing [BOP], periodontal probing depth [PPD] and periodontal inflamed surface area [PISA]) were analysed to explore the potential of dMRI to reflect disease status and inflammatory burden. Materials and Methods In this prospective study, patients with severe periodontitis underwent clinical examination, CBCT and 3T dMRI. Site-level detectability of periodontal osseous defects and/or marrow signal changes at the six standard clinical probing sites per tooth, as well as tooth-level lesion volumetry, were evaluated across CBCT, T1-weighted (T1W), contrast-enhanced T1W and T2-weighted (T2W). Reliability (κ, ICC) and clinical-imaging associations (Kruskal-Wallis and mixed-effect models) were analysed. Results Nineteen patients with severe periodontitis stages III and IV were included. Reliability of dMRI matched CBCT (site-level κ = 0.631-0.771; tooth-level ICC = 0.832-0.973). Increasing PPD and BOP raised lesion detectability and volumes across all modalities, with dMRI being consistently more sensitive than CBCT. T1W MRI showed lesions and bone loss similar to CBCT and was unaffected by BOP (p = 0.132) or PPD (p = 0.252). T2W MRI identified most lesions regardless of PPD and reflected high correlations with BOP (p < 0.05), PPD (p < 0.001) and PISA (p < 0.001). Conclusions Reliability of dMRI for lesion identification and quantification was comparable to that of CBCT. The presence of T2W marrow oedema at sites with a CBCT-normal periodontal ligament space and no radiographically detectable bone loss may represent a promising imaging marker for early periodontal disease recognition and assessment of inflammatory burden.
Descrizione del documento:Zuerst veröffentlicht: 17. Juni 2026
Gesehen am 04.09.2026
Descrizione fisica:Online Resource
ISSN:1600-051X
DOI:10.1111/jcpe.70151

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