Wiring of cellular proteostasis by J-domain proteins
Originally J-domain proteins (JDPs) were viewed as accessory co-chaperones of 70kDa heat shock proteins (Hsp70s), the actual chaperones, stimulating ATPase activity of Hsp70s when a protein substrate is bound. This view apparently underestimates the role of JDPs, as most of the decisions within the...
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| Main Author: | |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
July 2026
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| In: |
Cell stress & chaperones
Year: 2026, Volume: 31, Issue: 4, Pages: 1-13 |
| ISSN: | 1466-1268 |
| DOI: | 10.1016/j.cstres.2026.100191 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.cstres.2026.100191 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S1355814526000477 
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| Author Notes: | Matthias P. Mayer |
| Summary: | Originally J-domain proteins (JDPs) were viewed as accessory co-chaperones of 70kDa heat shock proteins (Hsp70s), the actual chaperones, stimulating ATPase activity of Hsp70s when a protein substrate is bound. This view apparently underestimates the role of JDPs, as most of the decisions within the Hsp70 network seems to be taken at the level of JDPs. The JDPs are the brain, so to speak, and the Hsp70s are the muscles of this chaperone network. |
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| Item Description: | Online verfügbar: 22. Mai 2026, Artikelversion: 2. Juni 2026 Gesehen am 04.09.2026 |
| Physical Description: | Online Resource |
| ISSN: | 1466-1268 |
| DOI: | 10.1016/j.cstres.2026.100191 |