Lysyl oxidase (LOX) family proteins in extracellular matrix homeostasis: roles in disease and radiation-induced pathogenesis : review
The extracellular matrix (ECM) not only provides structural support in tissues but also regulates cellular processes and tissue homeostasis. The lysyl oxidase (LOX) family of enzymes, consisting of LOX and lysyl oxidase-like enzymes (LOXL1-4), is involved in ECM remodeling by catalyzing the crosslin...
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| Autores principales: | , , , , , , |
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| Formato: | Article (Journal) |
| Lenguaje: | inglés |
| Publicado: |
December 2026
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| In: |
Molecular biology reports
Year: 2026, Volumen: 53, Número: 1, Pages: 1-18 |
| ISSN: | 1573-4978 |
| DOI: | 10.1007/s11033-026-12438-x |
| Acceso en línea: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s11033-026-12438-x
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| Notas de Autor: | Jingxian Yang, Vanessa Weyer, Ahmad Sami, Carsten Sticht, Frank A. Giordano, Carsten Herskind, Marlon R. Veldwijk |
| Sumario: | The extracellular matrix (ECM) not only provides structural support in tissues but also regulates cellular processes and tissue homeostasis. The lysyl oxidase (LOX) family of enzymes, consisting of LOX and lysyl oxidase-like enzymes (LOXL1-4), is involved in ECM remodeling by catalyzing the crosslinking of collagen and elastin. Dysregulation of these enzymes is implicated in the pathogenesis of various diseases, including organ fibrosis and tumor development. Furthermore, LOX family members have been shown to affect radiotherapy responses, with specific involvement in radioresistance and radiation-induced fibrosis. This review summarizes the structural and functional characteristics of the LOX family, highlighting their roles in fibrotic diseases such as pulmonary fibrosis, liver fibrosis, and cardiac diseases, their roles in tumor progression, relevance in radiotherapy, and treatment targeting LOX and LOXLs. Understanding the underlying mechanisms and potential therapies is critical for developing novel strategies in both disease identification and management. |
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| Notas: | Gesehen am 07.09.2026 Online veröffentlicht: 7. August 2026, Artikelversion: 7. August 2026 |
| Descripción Física: | Online Resource |
| ISSN: | 1573-4978 |
| DOI: | 10.1007/s11033-026-12438-x |