Nanomedicine-enabled tumor pyroptosis-immunotherapy: from material design and synergistic mechanisms to clinical perspectives
Emerging pyroptosis-immunotherapy strategies integrating functionalized nanoplatforms with pyroptosis inducers and immunomodulators show significant potential for treating primary, recurrent, and metastatic malignancies. Inducing pyroptosis directly ablates tumor cells and promotes immunogenic cell...
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| Autori principali: | , , , , , , , , |
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| Natura: | Article (Journal) |
| Lingua: | inglese |
| Pubblicazione: |
10 June 2026
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| In: |
Coordination chemistry reviews
Year: 2026, Volume: 566, Pages: 1-49 |
| ISSN: | 1873-3840 |
| DOI: | 10.1016/j.ccr.2026.218178 |
| Accesso online: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ccr.2026.218178 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0010854526006144 
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| Note sull'autore: | Xiao Wei, Yanqiu Jiang, Zhengxi Li, Junming Hu, Feiyang Chenwu, Feina Li, Mingzhu Song, Yan He, Jing Wang |
| Riassunto: | Emerging pyroptosis-immunotherapy strategies integrating functionalized nanoplatforms with pyroptosis inducers and immunomodulators show significant potential for treating primary, recurrent, and metastatic malignancies. Inducing pyroptosis directly ablates tumor cells and promotes immunogenic cell death (ICD), activating systemic antitumor immunity via the release of pro-inflammatory cytokines and damage-associated molecular patterns (DAMPs). However, limitations including low tumor immunogenicity and a restrictive immunosuppressive tumor microenvironment (TME) often hinder pyroptosis monotherapy from eliciting a robust systemic immune response. Synergistic strategies have thus been developed to enhance immune infiltration and restore immune surveillance, including: (1) directly boosting antitumor immunity; (2) disrupting the immunosuppressive niche; (3) remodeling the physical TME. Rational nanocarrier design is key to overcoming biological barriers and optimizing efficacy. Unlike prior reviews focusing separately on nanoparticles with pyroptosis or pyroptosis in immunotherapy, this article systematically analyzes the synergy of nanoparticles in combined pyroptosis-immunotherapy. It proposes multidimensional nanoplatform design principles covering material selection, structural configuration, physicochemical modulation, multifunctional integration, and artificial intelligence (AI)-assisted design, establishing a framework for therapeutic optimization. The review also addresses translational challenges at preclinical and clinical stages, proposes feasible solutions, and outlines future directions. Overall, this work provides systematic insights into advanced nanomaterial design and therapeutic strategies, charting a roadmap to accelerate clinical translation in tumor immunotherapy. |
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| Descrizione del documento: | Gesehen am 10.09.2026 |
| Descrizione fisica: | Online Resource |
| ISSN: | 1873-3840 |
| DOI: | 10.1016/j.ccr.2026.218178 |