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MiR-494-5p suppresses colorectal cancer metastasis by multi-level targeting of KAT2B, a novel mechanism disrupting KAT2B enhancer-promoter looping, and inhibiting c-JUN-driven pro-metastatic properties

Metastatic progression is the primary cause of death in colorectal cancer (CRC). However, the molecular networks governing CRC metastasis remain incompletely understood, representing a critical knowledge gap. MicroRNAs (miRNAs) are key post-transcriptional regulators frequently dysregulated in CRC,...

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Main Authors: Chen, Siche (Author) , Leupold, Jörg (Author) , Patil, Nitin (Author) , Xu, Peiren (Author) , Wang, Xinyu (Author) , Hu, Xinye (Author) , Allgayer, Heike (Author)
Format: Article (Journal)
Language:English
Published: December 2026
In: Molecular cancer
Year: 2026, Volume: 25, Issue: 1, Pages: 1-40
ISSN:1476-4598
DOI:10.1186/s12943-026-02703-9
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12943-026-02703-9
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Author Notes:Siche Chen, Jörg H. Leupold, Nitin S. Patil, Peiren Xu, Xinyu Wang, Xinye Hu and Heike Allgayer
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Summary:Metastatic progression is the primary cause of death in colorectal cancer (CRC). However, the molecular networks governing CRC metastasis remain incompletely understood, representing a critical knowledge gap. MicroRNAs (miRNAs) are key post-transcriptional regulators frequently dysregulated in CRC, yet their role in metastasis, particularly via non-canonical mechanisms, remains largely underexplored.
Item Description:Online veröffentlicht: 2. Juni 2026, Artikelversion: 20. August 2026
Gesehen am 14.09.2026
Physical Description:Online Resource
ISSN:1476-4598
DOI:10.1186/s12943-026-02703-9

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