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Clinical utility of sarcoma methylation classifiers in soft tissue sarcoma diagnosis

Soft tissue sarcomas are rare malignant tumors of mesenchymal origin characterized by their heterogeneity and diagnosis is challenging despite integrated histopathology and molecular testing. DNA methylation profiling offers an objective approach for tumor classification, but clinical implementation...

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Main Authors: Osterloh, Justus (Author) , Reuss, David (Author) , Deimling, Andreas von (Author) , Füllgraf, Hannah (Author) , Heyer, Jannis (Author) , Kurowski, Konrad (Author) , Kirchhof, Clara (Author) , Meiertoberens, Anna (Author) , Lausch, Ute (Author) , Schmid, Adrian (Author) , Eisenhardt, Steffen U. (Author) , Braig, David (Author) , Runkel, Alexander (Author)
Format: Article (Journal)
Language:English
Published: 6 May 2026
In: Journal of cancer research and clinical oncology
Year: 2026, Volume: 152, Issue: 5, Pages: 1-9
ISSN:1432-1335
DOI:10.1007/s00432-026-06494-w
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00432-026-06494-w
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Author Notes:Justus Osterloh, David E. Reuss, Andreas von Deimling, Hannah Füllgraf, Jannis Heyer, Konrad Kurowski, Clara Kirchhof, Anna Meiertoberens, Ute Lausch, Adrian Schmid, Steffen U. Eisenhardt, David Braig, Alexander Runkel
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Summary:Soft tissue sarcomas are rare malignant tumors of mesenchymal origin characterized by their heterogeneity and diagnosis is challenging despite integrated histopathology and molecular testing. DNA methylation profiling offers an objective approach for tumor classification, but clinical implementation data in soft tissue sarcoma remain limited.
Item Description:Gesehen am 15.09.2026
Physical Description:Online Resource
ISSN:1432-1335
DOI:10.1007/s00432-026-06494-w

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