APTw CEST MRI in therapy-naive IDH-wildtype glioblastoma: insights into tumor heterogeneity and molecular subtypes
Advanced MRI techniques may provide non-invasive insight into the molecular heterogeneity of glioblastoma. Amide proton transfer-weighted (APTw) chemical exchange saturation transfer (CEST) MRI reflects endogenous protein and peptide content, but its clinical and molecular correlates in therapy-naiv...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
19 May 2026
|
| In: |
Journal of neuro-oncology
Year: 2026, Volume: 178, Pages: 1-9 |
| ISSN: | 1573-7373 |
| DOI: | 10.1007/s11060-026-05616-1 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s11060-026-05616-1 |
| Author Notes: | Thomas Zeyen, Andreas Decker, Inga Krause, Florian Kroh, Julia Scheuble, Lea L. Friker, Torsten Pietsch, Sebastian Regnery, Alexander Effland, Johannes Weller, Niklas Schäfer, Alexander Radbruch, Ulrich Herrlinger, Daniel Paech |
| Summary: | Advanced MRI techniques may provide non-invasive insight into the molecular heterogeneity of glioblastoma. Amide proton transfer-weighted (APTw) chemical exchange saturation transfer (CEST) MRI reflects endogenous protein and peptide content, but its clinical and molecular correlates in therapy-naive glioblastoma, IDH-wildtype, remain incompletely understood. |
|---|---|
| Item Description: | Gesehen am 18.09.2026 |
| Physical Description: | Online Resource |
| ISSN: | 1573-7373 |
| DOI: | 10.1007/s11060-026-05616-1 |