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APTw CEST MRI in therapy-naive IDH-wildtype glioblastoma: insights into tumor heterogeneity and molecular subtypes

Advanced MRI techniques may provide non-invasive insight into the molecular heterogeneity of glioblastoma. Amide proton transfer-weighted (APTw) chemical exchange saturation transfer (CEST) MRI reflects endogenous protein and peptide content, but its clinical and molecular correlates in therapy-naiv...

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Autori principali: Zeyen, Thomas (Autore) , Decker, Andreas (Autore) , Krause, Inga (Autore) , Kroh, Florian (Autore) , Scheuble, Julia (Autore) , Friker, Lea L. (Autore) , Pietsch, Torsten (Autore) , Regnery, Sebastian (Autore) , Effland, Alexander (Autore) , Weller, Johannes (Autore) , Schäfer, Niklas (Autore) , Radbruch, Alexander (Autore) , Herrlinger, Ulrich (Autore) , Paech, Daniel (Autore)
Natura: Article (Journal)
Lingua:inglese
Pubblicazione: 19 May 2026
In: Journal of neuro-oncology
Year: 2026, Volume: 178, Pages: 1-9
ISSN:1573-7373
DOI:10.1007/s11060-026-05616-1
Accesso online:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s11060-026-05616-1
Testo
Note sull'autore:Thomas Zeyen, Andreas Decker, Inga Krause, Florian Kroh, Julia Scheuble, Lea L. Friker, Torsten Pietsch, Sebastian Regnery, Alexander Effland, Johannes Weller, Niklas Schäfer, Alexander Radbruch, Ulrich Herrlinger, Daniel Paech
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Riassunto:Advanced MRI techniques may provide non-invasive insight into the molecular heterogeneity of glioblastoma. Amide proton transfer-weighted (APTw) chemical exchange saturation transfer (CEST) MRI reflects endogenous protein and peptide content, but its clinical and molecular correlates in therapy-naive glioblastoma, IDH-wildtype, remain incompletely understood.
Descrizione del documento:Gesehen am 18.09.2026
Descrizione fisica:Online Resource
ISSN:1573-7373
DOI:10.1007/s11060-026-05616-1

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