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Dietary patterns associated with weight loss among patients with colorectal cancer during the first 6 months after diagnosis: a cross-sectional analysis from the ColoCare study

Background - Unintentional weight loss following a cancer diagnosis is associated with increased risk of adverse clinical outcomes. Nutrition guidance for the prevention of weight loss after cancer diagnosis is limited, particularly regarding optimal dietary patterns. - Objective - To identify commo...

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Autori principali: Hoobler, Rachel (Autore) , Tabung, Fred K. (Autore) , Lin, Tengda (Autore) , Gigić, Biljana (Autore) , Smith, Kristen S. (Autore) , Woodruff, Kary (Autore) , Crowder, Sylvia L. (Autore) , Hardikar, Sheetal (Autore) , Byrd, Doratha A. (Autore) , Coletta, Adriana M. (Autore) , Sanchez, Alejandro (Autore) , Chaix, Amandine (Autore) , Greathouse, K. Leigh (Autore) , Ilozumba, Mmadili N. (Autore) , Ose, Jennifer (Autore) , Damerell, Victoria (Autore) , Strehli, Ildiko (Autore) , McLaws, Megan (Autore) , Florou, Vaia (Autore) , Huang, Lyen C. (Autore) , Shibata, David (Autore) , Figueiredo, Jane C. (Autore) , Toriola, Adetunji T. (Autore) , Li, Christopher I. (Autore) , Ulrich, Cornelia (Autore) , Playdon, Mary C. (Autore)
Natura: Article (Journal)
Lingua:inglese
Pubblicazione: August 2026
In: Journal of the Academy of Nutrition and Dietetics
Year: 2026, Volume: 126, Fascicolo: 8, Pages: 1-24
ISSN:2212-2680
DOI:10.1016/j.jand.2026.156351
Accesso online:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.jand.2026.156351
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S2212267226000663
Testo
Note sull'autore:Rachel Hoobler, PhD, RDN; Fred K. Tabung, PhD, MSPH; Tengda Lin, MPH, MA; Biljana Gigic, PhD; Kristen S. Smith, PhD; Kary Woodruff, PhD, RDN, CSSD; Sylvia L. Crowder, PhD; Sheetal Hardikar, PhD, MPH, MBBS; Doratha A. Byrd, PhD, MPH; Adriana M. Coletta, PhD, MS, RDN; Alejandro Sanchez, MD; Amandine Chaix, PhD; K. Leigh Greathouse, PhD, MPH, MS, RDN; Mmadili N. Ilozumba, PhD; Jennifer Ose, PhD; Victoria Damerell, PhD, MSc; Ildiko Strehli, MA, MAEd, PhD; Megan McLaws; Vaia Florou, MD, MS; Lyen C. Huang, MD, MPH, FACS, FASCRS; David Shibata, MD, FACS, FSSO, FASCRS; Jane C. Figueiredo, PhD, MSc; Adetunji T. Toriola, MD, PhD, MPH; Christopher I. Li, MD, PhD, MPH; Cornelia M. Ulrich, PhD, MS; Mary C. Playdon, PhD, MPH
Descrizione
Riassunto:Background - Unintentional weight loss following a cancer diagnosis is associated with increased risk of adverse clinical outcomes. Nutrition guidance for the prevention of weight loss after cancer diagnosis is limited, particularly regarding optimal dietary patterns. - Objective - To identify common dietary patterns among a cohort of patients with colorectal cancer (CRC) and evaluate their associations with weight loss during the 6 months following CRC diagnosis. - Design - A cross-sectional analysis of data from CRC patients enrolled in the ColoCare Study between 2010 and 2021. - Participants/setting - Four hundred five patients newly diagnosed with CRC from 4 study sites located in Washington, Utah, Missouri, and California. Included participants completed a 6-month food frequency questionnaire and had self-reported weight data from study enrollment to 6 months. - Main outcome measures - The primary outcome was weight loss ≥5% from study enrollment to the 6-month follow-up visit. - Statistical analyses performed - Principal component analysis was leveraged to identify common dietary patterns, and Healthy Eating Index 2020 scores were calculated as a reference dietary pattern. Associations between adherence to dietary patterns (scaled to compare the 90th vs 10th percentile) and 6-month weight loss were evaluated using multivariable logistic regression. All tests were 2-sided. - Results - Four dietary patterns were identified: Western; Prudent; Refined Grain, Sugar, and Dairy; and High-Fat, High-Protein Foods. High compared with low adherence to the Refined Grain, Sugar, and Dairy dietary pattern was associated with greater odds of weight loss in the first 6 months following CRC diagnosis (odds ratio 2.04; 95% CI, 1.10 to 3.81; P = .02). There was evidence for effect modification by cancer type and history of unintentional weight loss at study enrollment. - Conclusions - These results highlight the potential for dietary patterns to influence weight loss during the first 6 months following a cancer diagnosis. Further research is needed to refine dietary guidance for patients with CRC to improve clinical outcomes.
Descrizione del documento:Gesehen am 23.09.2026
Descrizione fisica:Online Resource
ISSN:2212-2680
DOI:10.1016/j.jand.2026.156351

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