Malnutrition in childhood interstitial lung diseases is associated with reduced lung function and greater disease severity: insights from the chILD-EU registry
Background - Malnutrition is a recognized but insufficiently investigated concern in children with childhood interstitial lung diseases (chILD). The relationship between nutritional status and pulmonary function in this population remains poorly understood. This study aimed to evaluate the frequency...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
July 2026
|
| In: |
Respiratory medicine
Year: 2026, Volume: 258, Pages: 1-9 |
| ISSN: | 1532-3064 |
| DOI: | 10.1016/j.rmed.2026.108886 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.rmed.2026.108886 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0954611126002544 
|
| Author Notes: | Tugba Ramasli Gursoy, Nagehan Emiralioglu, Matthias Griese, Elias Seidl, Julia Rodler, Nicolaus Schwerk, Julia Carlens, Martin Wetzke, Nadia Nathan, Steve Cunningham, Joanna Lange, Katarzyna Krenke, Florian Stehling, Susanne Hämmerling, Marijke Proesmans, Nicola Ullmann, Frederik Buchvald, Antonio Moreno Galdo, Ayse Tana Aslan, Nazan Cobanoglu, Nural Kiper, chILD-EU Register and chILD-EU CRC collaborators |
| Summary: | Background - Malnutrition is a recognized but insufficiently investigated concern in children with childhood interstitial lung diseases (chILD). The relationship between nutritional status and pulmonary function in this population remains poorly understood. This study aimed to evaluate the frequency and impact of malnutrition in chILD and to identify associated clinical factors. - Methods - We analyzed baseline and follow-up data from the chILD-EU registry, including anthropometric measurements, disease severity scores, pulmonary function tests, and treatment information. Malnutrition was defined as a weight-for-age (WFA) z-score < −2. Multivariable linear regression models were used to assess the association between malnutrition and lung function after adjustment for potential confounders. Longitudinal mixed-effects models were applied to evaluate the relationship between time-varying nutritional status and lung function over time. - Results - A total of 3351 visits from 766 children were analyzed. At baseline, 38.9% of children were malnourished. Children with malnutrition had significantly lower lung function compared with those without malnutrition (both p<0.001). In multivariable analyses adjusting for age, sex, prematurity, diagnostic category, and disease severity, malnutrition remained independently associated with reduced lung function (zFEV1 β=−0.83, p=0.007; zFVC β=−1.35, p<0.001). In longitudinal mixed-effects models including baseline and follow-up visits, improvements in WFA z-scores were associated with improved lung function over time (zFEV1 β=0.33, p<0.001; zFVC β=0.37, p<0.001). - Conclusion - Malnutrition is common among children with chILD and is independently associated with impaired lung function and greater disease severity. Improvements in nutritional status are associated with improved pulmonary outcomes during follow-up, highlighting the importance of routine nutritional monitoring and multidisciplinary care. |
|---|---|
| Item Description: | Online verfügbar: 12 May 2026 Gesehen am 24.09.2026 |
| Physical Description: | Online Resource |
| ISSN: | 1532-3064 |
| DOI: | 10.1016/j.rmed.2026.108886 |