Cover Image

(18F)Fluorodeoxyglucose positron emission tomography for detection of bone marrow involvement in children and adolescents with Hodgkin's lymphoma

PURPOSE: Currently, a routine bone marrow biopsy (BMB) is performed to detect bone marrow (BM) involvement in pediatric Hodgkin's lymphoma (HL) stage greater than IIA. [(18)F]fluorodeoxyglucose positron emission tomography (FDG-PET) is increasingly used for the initial staging of HL. The value...

Full description

Saved in:
Bibliographic Details
Main Authors: Purz, Sandra (Author) , Mauz-Körholz, Christine (Author) , Körholz, Dieter (Author) , Hasenclever, Dirk (Author) , Krauße, Antje (Author) , Sorge, Ina (Author) , Ruschke, Kathrin (Author) , Stiefel, Martina (Author) , Amthauer, Holger (Author) , Schober, Otmar (Author) , Kranert, W. Tilman (Author) , Weber, Wolfgang Andreas (Author) , Haberkorn, Uwe (Author) , Hundsdörfer, Patrick (Author) , Ehlert, Karoline (Author) , Becker, Martina (Author) , Rößler, Jochen (Author) , Kulozik, Andreas (Author) , Sabri, Osama (Author) , Kluge, Regine (Author)
Format: Article (Journal)
Language:English
Published: August 8, 2011
In: Journal of clinical oncology
Year: 2011, Volume: 29, Issue: 26, Pages: 3523-3528
ISSN:1527-7755
DOI:10.1200/JCO.2010.32.4996
Online Access:Resolving-System, lizenzpflichtig, Volltext: http://doi.org/10.1200/JCO.2010.32.4996
Verlag, Volltext: http://jco.ascopubs.org/content/29/26/3523.abstract?sid=f258e801-cf64-4442-ba4e-da7902465220
Get full text
Author Notes:hSandra Purz, Christine Mauz-Körholz, Dieter Körholz, Dirk Hasenclever, Antje Krausse, Ina Sorge, Kathrin Ruschke, Martina Stiefel, Holger Amthauer, Otmar Schober, W. Tilman Kranert, Wolfgang A. Weber, Uwe Haberkorn, Patrick Hundsdörfer, Karoline Ehlert, Martina Becker, Jochen Rössler, Andreas E. Kulozik, Osama Sabri, and Regine Kluge
Description
Summary:PURPOSE: Currently, a routine bone marrow biopsy (BMB) is performed to detect bone marrow (BM) involvement in pediatric Hodgkin's lymphoma (HL) stage greater than IIA. [(18)F]fluorodeoxyglucose positron emission tomography (FDG-PET) is increasingly used for the initial staging of HL. The value of using FDG-PET to detect BM involvement has not been sufficiently defined. We compared the results of BMBs and FDG-PET for the diagnosis of BM involvement in a large pediatric group with HL. - PATIENTS AND METHODS: The initial staging of 175 pediatric patients with newly diagnosed classical HL stage greater than IIA was determined by using BMB, FDG-PET, chest computed tomography (CT), and magnetic resonance imaging (MRI) or CT of the neck, abdomen, and pelvis. Staging images were prospectively evaluated by a central review board. Skeletal regions that were suggestive of BM involvement by either method were re-evaluated by using different imaging modalities. In suspicious cases, bone scintigraphy was performed. If follow-up FDG-PET scans were available, the remission of skeletal lesions during treatment was evaluated. - RESULTS: BMB results were positive in seven of 175 patients and were identified by FDG-PET. FDG-PET scans showed BM involvement in 45 patients. In addition, the lesions of 32 of these 45 patients had a typical multifocal pattern. In 38 of 39 follow-up positron emission tomography scans, most of the skeletal lesions disappeared after chemotherapy. There was no patient with skeletal findings suggestive of BM involvement by MRI or CT with a negative FDG-PET. - CONCLUSION: FDG-PET is a sensitive and specific method for the detection of BM involvement in pediatric HL. The sensitivity of a BMB appears compromised by the focal pattern of BM involvement. Thus, FDG-PET may safely be substituted for a BMB in routine staging procedures.
Item Description:Im Titel steht der Ausdruck (18F) in eckider Klammer, die Zahl "18" ist dabei hochgestellt
Physical Description:Online Resource
ISSN:1527-7755
DOI:10.1200/JCO.2010.32.4996

Similar Items