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Renal cell neoplasias: reversion-inducing cysteine-rich protein with Kazal motifs discriminates tumor subtypes, while extracellular matrix metalloproteinase inducer indicates prognosis

Matrix metalloproteinases can promote invasion and metastasis, which are very frequent in renal cell carcinoma even at the time of diagnosis. Knowing the reversion-inducing cysteine-rich protein with Kazal motifs (RECK) as an inhibitor of matrix metalloproteinases and the extracellular matrix metall...

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Main Authors: Rabien, Anja (Author) , Stephan, Carsten (Author) , Kilic, Ergin (Author) , Weichert, Wilko (Author) , Kristiansen, Glen (Author) , Miller, Kurt (Author) , Jung, Klaus (Author) , Erbersdobler, Andreas (Author)
Format: Article (Journal)
Language:English
Published: 16 October 2013
In: Journal of translational medicine
Year: 2013, Volume: 11, Pages: 1-9
ISSN:1479-5876
DOI:10.1186/1479-5876-11-258
Online Access:Verlag, Volltext: http://www.translational-medicine.com/content/11/1/258
Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1479-5876-11-258
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Author Notes:Anja Rabien, Carsten Stephan, Ergin Kilic, Wilko Weichert, Glen Kristiansen, Kurt Miller, Klaus Jung and Andreas Erbersdobler
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Summary:Matrix metalloproteinases can promote invasion and metastasis, which are very frequent in renal cell carcinoma even at the time of diagnosis. Knowing the reversion-inducing cysteine-rich protein with Kazal motifs (RECK) as an inhibitor of matrix metalloproteinases and the extracellular matrix metalloproteinase inducer (EMMPRIN) protein as inducer, we aimed to determine their expression, localization and possible antagonistic action in the pathogenesis and progression of renal cell tumors in a retrospective study.
Item Description:Gesehen am 10.12.2021
Physical Description:Online Resource
ISSN:1479-5876
DOI:10.1186/1479-5876-11-258

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