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Pediatric herpes simplex virus encephalitis: a retrospective multicenter experience

Knowledge on pediatric herpes simplex virus encephalitis is limited. Here we summarize 6 neonates and 32 children diagnosed bypolymerase chain reaction (n=37) or serological studies (n=1), respectively. Diagnosis was difficult, as only 15 patientspresented neurologic symptoms. Moreover, cerebrospina...

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Main Author: Schleede, Lena (Author)
Other Authors: Büter, Wolfgang (Other) , Baumgartner-Sigl, Sara (Other) , Opladen, Thomas (Other) , Weigt-Usinger, Katharina (Other) , Stephan, Susanne (Other) , Smitka, Martin (Other) , Leiz, Steffen (Other) , Kaiser, Olaf (Other) , Kraus, Verena (Other) , Baalen, Andreas van (Other) , Skopnik, Heino (Other) , Hartmann, Hans (Other) , Rostasy, Kevin (Other) , Lücke, Thomas (Other) , Schara, Ulrike (Other) , Häusler, Martin (Other)
Format: Article (Journal)
Language:English
Published: January 16, 2013
In: Journal of child neurology
Year: 2013, Volume: 28, Issue: 3, Pages: 321-331
ISSN:1708-8283
DOI:10.1177/0883073812471428
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1177/0883073812471428
Verlag, Abstract, Volltext: http://jcn.sagepub.com/content/28/3/321.abstract
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Author Notes:Lena Schleede, Wolfgang Bueter, Sara Baumgartner-Sigl, Thomas Opladen, Katharina Weigt-Usinger, Susanne Stephan, Martin Smitka, Steffen Leiz, Olaf Kaiser, Verena Kraus, Andreas van Baalen, Heino Skopnik, Hans Hartmann, Kevin Rostasy, Thomas Lu ̈cke, Ulrike Schara, and Martin Häusler
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Summary:Knowledge on pediatric herpes simplex virus encephalitis is limited. Here we summarize 6 neonates and 32 children diagnosed bypolymerase chain reaction (n=37) or serological studies (n=1), respectively. Diagnosis was difficult, as only 15 patientspresented neurologic symptoms. Moreover, cerebrospinal fluid glucose, protein, and leukocytes were normal in 6 patients.Subsequently, all but 2 showed neurologic symptoms. Diffusion-weighted neuroimaging was the most sensitive early imagingmethod. Despite acyclovir treatment, 8 patients experienced early relapses, showing movement abnormalities, impaired vigilance,and seizures. Diffuse white matter changes, found in 3 of 5 relapse patients on neuroimaging, and a negative cerebrospinal fluidherpes simplex virus polymerase chain reaction suggested inflammatory processes. All relapse patients were again treated withacyclovir, and 3 responded to additional corticosteroid treatment. Whereas outcome after relapses was poor, overall outcomewas good. No child died; 14 were asymptomatic at discharge, and neuroimaging remained normal in 7 of 30 patients studied.
Item Description:Gesehen am 01.07.2021
Physical Description:Online Resource
ISSN:1708-8283
DOI:10.1177/0883073812471428

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