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Local tumor control probability modeling of primary and secondary lung tumors in stereotactic body radiotherapy

Background and purpose: To evaluate whether local tumor control probability (TCP) in stereotactic body radiotherapy (SBRT) varies between lung metastases of different primary cancer sites and between primary non-small cell lung cancer (NSCLC) and secondary lung tumors. Materials and methods: A retro...

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Main Authors: Guckenberger, Matthias (Author) , Klement, Rainer J. (Author) , Allgäuer, Michael (Author) , Andratschke, Nicolaus (Author) , Blanck, Oliver (Author) , Boda-Heggemann, Judit (Author) , Dieckmann, Karin (Author) , Duma, Marciana (Author) , Ernst, Iris (Author) , Ganswindt, Ute (Author) , Hass, Peter (Author) , Henkenberens, Christoph (Author) , Holy, Richard (Author) , Imhoff, Detlef (Author) , Kahl, Klaus-Henning (Author) , Krempien, Robert (Author) , Lohaus, Fabian (Author) , Nestle, Ursula (Author) , Nevinny-Stickel, Meinhard (Author) , Petersen, Cordula (Author) , Semrau, Sabine (Author) , Streblow, Jan (Author) , Wendt, Thomas G. (Author) , Wittig, Andrea (Author) , Flentje, Michael (Author) , Sterzing, Florian (Author)
Format: Article (Journal)
Language:English
Published: 2016
In: Radiotherapy and oncology
Year: 2015, Volume: 118, Issue: 3, Pages: 485-491
ISSN:1879-0887
DOI:10.1016/j.radonc.2015.09.008
Online Access:Verlag, Volltext: http://dx.doi.org/10.1016/j.radonc.2015.09.008
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0167814015004661
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Author Notes:Matthias Guckenberger, Rainer J. Klement, Michael Allgäuer, Nicolaus Andratschke, Oliver Blanck, Judit Boda-Heggemann, Karin Dieckmann, Marciana Duma, Iris Ernst, Ute Ganswindt, Peter Hass, Christoph Henkenberens, Richard Holy, Detlef Imhoff, Henning K. Kahl, Robert Krempien, Fabian Lohaus, Ursula Nestle, Meinhard Nevinny-Stickel, Cordula Petersen, Sabine Semrau, Jan Streblow, Thomas G. Wendt, Andrea Wittig, Michael Flentje, Florian Sterzing
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Summary:Background and purpose: To evaluate whether local tumor control probability (TCP) in stereotactic body radiotherapy (SBRT) varies between lung metastases of different primary cancer sites and between primary non-small cell lung cancer (NSCLC) and secondary lung tumors. Materials and methods: A retrospective multi-institutional (n=22) database of 399 patients with stage I NSCLC and 397 patients with 525 lung metastases was analyzed. Irradiation doses were converted to biologically effective doses (BED). Logistic regression was used for local tumor control probability (TCP) modeling and the second-order bias corrected Akaike Information Criterion was used for model comparison. Results: After median follow-up of 19months and 16months (n.s.), local tumor control was observed in 87.7% and 86.7% of the primary and secondary lung tumors (n.s.), respectively. A strong dose-response relationship was observed in the primary NSCLC and metastatic cohort but dose-response relationships were not significantly different: the TCD90 (dose to achieve 90% TCP; BED of maximum planning target volume dose) estimates were 176Gy (151-223) and 160Gy (123-237) (n.s.), respectively. The dose-response relationship was not influenced by the primary cancer site within the metastatic cohort. Conclusions: Dose-response relationships for local tumor control in SBRT were not different between lung metastases of various primary cancer sites and between primary NSCLC and lung metastases.
Item Description:Available online 15 September 2015
Physical Description:Online Resource
ISSN:1879-0887
DOI:10.1016/j.radonc.2015.09.008

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