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1,25-dihydroxyvitamin D3 inhibits corneal wound healing in an ex-vivo mouse model

Impaired healing of corneal injuries can result in ulceration and complete loss of vision, especially in the elderly. Such patients frequently also exhibit vitamin D insufficiency. 1,25-dihydroxyvitamin D3 is the active vitamin D metabolite. As it affects cell proliferation and inflammation, we here...

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Bibliographic Details
Main Authors: Sel, Saadettin (Author) , Trau, Stefanie (Author) , Paulsen, Friedrich (Author) , Kalinski, Thomas (Author) , Stangl, Gabriele I. (Author) , Naß, Norbert (Author)
Format: Article (Journal)
Language:English
Published: 21 January 2016
In: Graefe's archive for clinical and experimental ophthalmology
Year: 2016, Volume: 254, Issue: 4, Pages: 717-724
ISSN:1435-702X
DOI:10.1007/s00417-016-3267-4
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00417-016-3267-4
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Author Notes:Saadettin Sel, Stefanie Trau, Friedrich Paulsen, Thomas Kalinski, Gabriele I. Stangl, Norbert Nass
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Summary:Impaired healing of corneal injuries can result in ulceration and complete loss of vision, especially in the elderly. Such patients frequently also exhibit vitamin D insufficiency. 1,25-dihydroxyvitamin D3 is the active vitamin D metabolite. As it affects cell proliferation and inflammation, we herein aimed at elucidating its influence on corneal wound healing after alkali burn by using in vitro and ex vivo techniques.
Item Description:Im Titel ist die Zahl 3 tiefgestellt
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Physical Description:Online Resource
ISSN:1435-702X
DOI:10.1007/s00417-016-3267-4

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