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Lack of CYP3A4 protein induction despite mRNA induction in primary hepatocytes exposed to rifabutin as a possible explanation for its low interaction risk in vivo
by Nilles, Julie (Author)
, Theile, Dirk (Author)
, Weiß, Johanna (Author)
, Haefeli, Walter E. (Author)
, Ruez, Stephanie (Author)
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Archives of toxicology, 98 (2024), 8 vom: Aug., Seite 2541-2556
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In vitro evidence suggesting that the toll-like receptor 7 and 8 agonist resiquimod (R-848) unlikely affects drug levels of co-administered compounds
by Theile, Dirk (Author)
, Wagner, Lelia (Author)
, Haefeli, Walter E. (Author)
, Weiß, Johanna (Author)
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European journal of pharmaceutical sciences, 162 (2021) vom: 1. Juli, Artikel-ID 105826, Seite 1-7
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Reduced clearance of venlafaxine in a combined treatment with quetiapine
by Paulzen, Michael (Author)
, Gründer, Gerhard (Author)
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Progress in neuro-psychopharmacology & biological psychiatry, 85 (2018), Seite 116-121
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Medizinische Fakultät Heidelberg
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Klinikum der Universität Heidelberg
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Zentrum für Innere Medizin (Krehl Klinik)
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Institute of Pharmacy and Molecular Biotechnology
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Medizinische Fakultät Mannheim
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Haefeli, Walter E.
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Theile, Dirk
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Weiß, Johanna
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Gründer, Gerhard
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Nilles, Julie
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Paulzen, Michael
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Ruez, Stephanie
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Wagner, Lelia
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CYP3A4
ATP Binding Cassette Transporter, Subfamily B
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ATP Binding Cassette Transporter, Subfamily B, Member 1
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Cells, Cultured
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Cytochrome P-450 CYP3A
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Cytochrome P-450 CYP3A Inducers
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Drug Interactions
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Drug transporter
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Drug-drug interaction
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Enzyme Induction
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Hepatocytes
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Humans
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Induction
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Male
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Nuclear factor kappa B
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P-gp
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Pharmacokinetic interactions
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Pregnane x receptor
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Primary human hepatocyte
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Quetiapine
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RNA, Messenger
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Resiquimod
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Rifabutin
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Rifampicin
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Rifampin
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Tandem Mass Spectrometry
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Therapeutic drug monitoring
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Venlafaxine
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