Search Results - "proteases"

Antiviral drug discovery with an optimized biochemical dengue protease assay: Improved predictive power for antiviral efficacy by Lang, Johannes (Author) , Dutta, Sudip Kumar (Author) , Leuthold, Mila (Author) , Reichert, Lisa (Author) , Kühl, Nikos (Author) , Martina, Byron (Author) , Klein, Christian D. (Author) ,

Subjects: “…NS3 PROTEASE…”

• Verlag, lizenzpflichtig, Volltext
• Verlag, lizenzpflichtig, Volltext

Direct neuronal protection by the protease-activated receptor PAR4 antagonist ML354 after experimental stroke in mice by Fleischer, Michael (Author) , Szepanowski, Rebecca D. (Author) , Pesara, Valeria (Author) , Bihorac, Julia Sophie (Author) , Oehler, Beatrice (Author) , Dobrev, Dobromir (Author) , Kleinschnitz, Christoph (Author) , Fender, Anke C. (Author) ,

Subjects: “…protease-activated receptor…”

• Verlag, kostenfrei, Volltext
• Verlag, kostenfrei, Volltext

Alternate recognition by dengue protease: proteolytic and binding assays provide functional evidence beyond an induced-fit by Behnam, Mira A. M. (Author) , Klein, Christian D. (Author) ,

Subjects: “…Protease…”

• Verlag, kostenfrei, Volltext
• Verlag, kostenfrei, Volltext

In vivo characterization of the bacterial intramembrane-cleaving protease RseP using the heme binding tag-based assay iCliPSpy by Kupke, Thomas (Author) , Götz, Rabea (Author) , Richter, Florian M. (Author) , Beck, Rainer (Author) , Lolicato, Fabio (Author) , Nickel, Walter (Author) , Hopf, Carsten (Author) , Brügger, Britta (Author) ,

Subjects: “…Proteases…”

• Verlag, kostenfrei, Volltext
• Verlag, kostenfrei, Volltext

N-sulfonyl peptide-hybrids as a new class of dengue virus protease inhibitors by Behrouz, Somayeh (Author) , Kühl, Nikos (Author) , Klein, Christian D. (Author) ,

Subjects: “…NS2B-NS3 protease…”

• Verlag, lizenzpflichtig, Volltext
• Verlag, lizenzpflichtig, Volltext

2,2′-Bithiophene as sensor tag for ligand-protein binding assays based on Förster resonance energy transfer by Behnam, Mira A. M. (Author) , Basché, Thomas (Author) , Klein, Christian D. (Author) ,

Subjects: “…Protease…”

• Verlag, lizenzpflichtig, Volltext
• Verlag, lizenzpflichtig, Volltext

Mice heterozygous for an osteogenesis imperfecta-linked MBTPS2 variant display a compromised subchondral osteocyte lacunocanalicular network associated with abnormal articular cart... by Danyukova, Tatyana (Author) , Alimy, Assil-Ramin (Author) , Velho, Renata Voltolini (Author) , Yorgan, Timur A. (Author) , Di Lorenzo, Giorgia (Author) , von Kroge, Simon (Author) , Tidow, Henning (Author) , Wiegert, Simon (Author) , Hermans-Borgmeyer, Irm (Author) , Schinke, Thorsten (Author) , Rolvien, Tim (Author) , Pohl, Sandra (Author) ,

Subjects: “…Site-2 protease…”

• Verlag, lizenzpflichtig, Volltext
• Verlag, lizenzpflichtig, Volltext

Discovery of TCMs and derivatives against the main protease of SARS-CoV-2 via high throughput screening, ADMET analysis, and inhibition assay in vitro by Qi, Xinyu (Author) , Li, Binglin (Author) , Omarini, Alejandra B. (Author) , Gand, Martin (Author) , Zhang, Xiaoli (Author) , Wang, Jiao (Author) ,

Subjects: “…Main protease (M)…”

• Verlag, lizenzpflichtig, Volltext
• Verlag, lizenzpflichtig, Volltext

Antibacterial peptide CyclomarinA creates toxicity by deregulating the Mycobacterium tuberculosis ClpC1-ClpP1P2 protease by Taylor, Gabrielle (Author) , Frommherz, Yannick (Author) , Katikaridis, Panagiotis (Author) , Layer, Dominik Christian (Author) , Sinning, Irmgard (Author) , Carroni, Marta (Author) , Weber-Ban, Eilika (Author) , Mogk, Axel (Author) ,

Subjects: “…protease…”

• Verlag, lizenzpflichtig, Volltext
• Verlag, lizenzpflichtig, Volltext

Cleavage of mitochondrial homeostasis regulator PGAM5 by the intramembrane protease PARL is governed by transmembrane helix dynamics and oligomeric state by Siebert, Verena (Author) , Silber, Mara (Author) , Heuten, Elena (Author) , Muhle-Goll, Claudia (Author) , Lemberg, Marius (Author) ,

Subjects: “…rhomboid serine protease…”

• Verlag, kostenfrei, Volltext
• Verlag, kostenfrei, Volltext

Tetraspanin 8 subfamily members regulate substrate-specificity of a disintegrin and metalloprotease 17 by Müller, Miryam (Author) , Saunders, Claire (Author) , Senftleben, Anke (Author) , Heidbüchel, Johannes P. W. (Author) , Halwachs, Birgit (Author) , Bolik, Julia (Author) , Hedemann, Nina (Author) , Röder, Christian (Author) , Bauerschlag, Dirk (Author) , Rose-John, Stefan (Author) , Schmidt-Arras, Dirk (Author) ,

Subjects: “…proteases…”

• Verlag, lizenzpflichtig, Volltext
• Verlag, lizenzpflichtig, Volltext

Characterization of a multipurpose NS3 surface patch coordinating HCV replicase assembly and virion morphogenesis by Isken, Olaf (Author) , Pham, Minh Tu (Author) , Schwanke, Hella (Author) , Schlotthauer, Felicia (Author) , Bartenschlager, Ralf (Author) , Tautz, Norbert (Author) ,

Subjects: “…serine-protease…”

• Resolving-System, kostenfrei, Volltext
• Verlag, kostenfrei, Volltext

Protein structural heterogeneity: a hypothesis for the basis of proteolytic recognition by the main protease of SARS-CoV and SARS-CoV-2 by Behnam, Mira A. M. (Author)

Subjects: “…Viral protease…”

• Verlag, lizenzpflichtig, Volltext
• Verlag, lizenzpflichtig, Volltext

Interleukin-11 (IL-11) receptor cleavage by the rhomboid protease RHBDL2 induces IL-11 trans-signaling by Koch, Lydia (Author) , Kespohl, Birte (Author) , Agthe, Maria (Author) , Schumertl, Tim (Author) , Düsterhöft, Stefan (Author) , Lemberg, Marius (Author) , Lokau, Juliane (Author) , Garbers, Christoph (Author) ,

Subjects: “…protease…”

• Resolving-System, kostenfrei
• Resolving-System, kostenfrei
• Resolving-System, kostenfrei
• Verlag, lizenzpflichtig, Volltext

Omics profiling of S2P mutant fibroblasts as a mean to unravel the pathomechanism and molecular signatures of X-linked MBTPS2 osteogenesis imperfecta by Lim, Pei Jin (Author) , Marfurt, Severin (Author) , Lindert, Uschi (Author) , Opitz, Lennart (Author) , Ndarugendamwo, Timothée (Author) , Srikanthan, Pakeerathan (Author) , Poms, Martin (Author) , Hersberger, Martin (Author) , Langhans, Claus-Dieter (Author) , Haas, Dorothea (Author) , Rohrbach, Marianne (Author) , Giunta, Cecilia (Author) ,

Subjects: “…Site 2 protease…”

• Verlag, lizenzpflichtig, Volltext
• Verlag, lizenzpflichtig, Volltext

Multi-antigen imaging reveals inflammatory DC, ADAM17 and neprilysin as effectors in keloid formation by Rath, Mathias (Author) , Pitiot, Alain (Author) , Kirr, Michael (Author) , Fröhlich, Waltraud (Author) , Plosnita, Bianca (Author) , Schliep, Stefan (Author) , Bauerschmitz, Jürgen (Author) , Baur, Andreas S. (Author) , Ostalecki, Christian (Author) ,

Subjects: “…proteases…”

• Verlag, lizenzpflichtig, Volltext
• Verlag, lizenzpflichtig, Volltext

SAR of novel benzothiazoles targeting an allosteric pocket of DENV and ZIKV NS2B/NS3 proteases by Maus, Hannah (Author) , Barthels, Fabian (Author) , Hammerschmidt, Stefan Josef (Author) , Kopp, Katja (Author) , Millies, Benedikt (Author) , Gellert, Andrea (Author) , Ruggieri, Alessia (Author) , Schirmeister, Tanja (Author) ,

Subjects: “…NS2B/NS3 protease…”

• Verlag, lizenzpflichtig, Volltext
• Verlag, lizenzpflichtig, Volltext

The spectrum between substrates and inhibitors: Pinpointing the binding mode of dengue protease ligands with modulated basicity and hydrophobicity by Dražić, Tonko (Author) , Kühl, Nikos (Author) , Gottscheber, Nicole (Author) , Hacker, Christina N. (Author) , Klein, Christian D. (Author) ,

Subjects: “…Flaviviral protease…”

• Verlag, lizenzpflichtig, Volltext
• Verlag, lizenzpflichtig, Volltext

Insights into the catalytic properties of the mitochondrial rhomboid protease PARL by Lysyk, Laine (Author) , Brassard, Raelynn (Author) , Arutyunova, Elena (Author) , Siebert, Verena (Author) , Jiang, Zhenze (Author) , Takyi, Emmanuella (Author) , Morrison, Melissa (Author) , Young, Howard S. (Author) , Lemberg, Marius (Author) , O’Donoghue, Anthony J. (Author) , Lemieux, M. Joanne (Author) ,

Subjects: “…membrane protease…”

• Verlag, kostenfrei, Volltext
• Verlag, kostenfrei, Volltext

TMPRSS2 expression dictates the entry route used by SARS-CoV-2 to infect host cells by Koch, Jana (Author) , Uckeley, Zina Maria (Author) , Doldan, Patricio (Author) , Stanifer, Megan (Author) , Boulant, Steeve (Author) , Lozach, Pierre-Yves (Author) ,

Subjects: “…protease…”

• Verlag, kostenfrei, Volltext
• Verlag, kostenfrei, Volltext