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Optogenetic control of RhoA reveals zyxin-mediated elasticity of stress fibres

Cellular contractility is regulated by the GTPase RhoA, but how local signals are translated to a cell-level response is not known. Here the authors show that targeted RhoA activation results in propagation of force along stress fibres and actin flow.

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Bibliographic Details
Main Authors: Oakes, Patrick W. (Author) , Brand, Christoph A. (Author) , Probst, Dimitri (Author) , Linke, Marco (Author) , Schwarz, Ulrich S. (Author)
Format: Article (Journal)
Language:English
Published: 12 Jun 2017
In: Nature Communications
Year: 2017, Volume: 8
ISSN:2041-1723
DOI:10.1038/ncomms15817
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1038/ncomms15817
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/ncomms15817
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Author Notes:Patrick W. Oakes, Elizabeth Wagner, Christoph A. Brand, Dimitri Probst, Marco Linke, Ulrich S. Schwarz, Michael Glotzer & Margaret L. Gardel
Description
Summary:Cellular contractility is regulated by the GTPase RhoA, but how local signals are translated to a cell-level response is not known. Here the authors show that targeted RhoA activation results in propagation of force along stress fibres and actin flow.
Item Description:Gesehen am 28.06.2017
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/ncomms15817

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