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Combined targeted DNA and RNA sequencing of advanced NSCLC in routine molecular diagnostics: analysis of the first 3000 Heidelberg cases

Here, we demonstrate the feasibility and clinical utility of comprehensive, NGS-based genetic profiling for routine workup of advanced NSCLC based on the first 3000 patients analyzed in our department

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Main Authors: Volckmar, Anna-Lena (Author) , Leichsenring, Jonas (Author) , Kirchner, Martina (Author) , Christopoulos, Petros (Author) , Neumann, Olaf (Author) , Budczies, Jan (Author) , Oliveira, Cristiano (Author) , Rempel, Eugen (Author) , Buchhalter, Ivo (Author) , Brandt, Regine (Author) , Allgäuer, Michael (Author) , Talla, Suranand Babu (Author) , Winterfeld, Moritz von (Author) , Herpel, Esther (Author) , Goeppert, Benjamin (Author) , Lier, Amelie (Author) , Winter, Hauke (Author) , Fröhling, Stefan (Author) , Heußel, Claus Peter (Author) , Herth, Felix (Author) , Lasitschka, Felix (Author) , Schirmacher, Peter (Author) , Thomas, Michael (Author) , Endris, Volker (Author) , Penzel, Roland (Author) , Stenzinger, Albrecht (Author)
Format: Article (Journal)
Language:English
Published: 17 January 2019
In: International journal of cancer
Year: 2019, Volume: 145, Issue: 3, Pages: 649-661
ISSN:1097-0215
DOI:10.1002/ijc.32133
Online Access:Resolving-System, Volltext: http://dx.doi.org/10.1002/ijc.32133
Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32133
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Author Notes:Anna-Lena Volckmar, Jonas Leichsenring, Martina Kirchner, Petros Christopoulos, Olaf Neumann, Jan Budczies, Cristiano Manuel Morais de Oliveira, Eugen Rempel, Ivo Buchhalter, Regine Brandt, Michael Allgäuer, Suranand Babu Talla, Moritz von Winterfeld, Esther Herpel, Benjamin Goeppert, Amelie Lier, Hauke Winter, Tilman Brummer, Stefan Fröhling, Martin Faehling, Jürgen R. Fischer, Claus Peter Heußel, Felix Herth, Felix Lasitschka, Peter Schirmacher, Michael Thomas, Volker Endris, Roland Penzel and Albrecht Stenzinger
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Summary:Here, we demonstrate the feasibility and clinical utility of comprehensive, NGS-based genetic profiling for routine workup of advanced NSCLC based on the first 3000 patients analyzed in our department
Item Description:Accepted manuscript online: 17 January 2019
Gesehen am 18.02.2019
Physical Description:Online Resource
ISSN:1097-0215
DOI:10.1002/ijc.32133

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