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Adamantinomatous and papillary craniopharyngiomas are characterized by distinct epigenomic as well as mutational and transcriptomic profiles

Craniopharyngiomas (CP) are rare epithelial tumors of the sellar region. Two subtypes, adamantinomatous (adaCP) and papillary CP (papCP), were previously identified based on histomorphological and epidemiological aspects. Recent data indicates that both variants are defined by specific genetic alter...

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Bibliographic Details
Main Authors: Hölsken, Annett (Author) , Sill, Martin (Author) , Pfister, Stefan (Author) , Deimling, Andreas von (Author) , Capper, David (Author) , Jones, David T. W. (Author)
Format: Article (Journal)
Language:English
Published: 29 February 2016
In: Acta Neuropathologica Communications
Year: 2016, Volume: 4, Pages: 1-13
ISSN:2051-5960
DOI:10.1186/s40478-016-0287-6
Online Access:Verlag, Volltext: https://doi.org/10.1186/s40478-016-0287-6
Verlag: https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-016-0287-6
Verlag: https://doi.org/10.1186/s40478-016-0287-6
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Author Notes:Annett Hölsken, Martin Sill, Jessica Merkle, Leonille Schweizer, Michael Buchfelder, Jörg Flitsch, Rudolf Fahlbusch, Markus Metzler, Marcel Kool, Stefan M. Pfister, Andreas von Deimling, David Capper, David T.W. Jones and Rolf Buslei
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Summary:Craniopharyngiomas (CP) are rare epithelial tumors of the sellar region. Two subtypes, adamantinomatous (adaCP) and papillary CP (papCP), were previously identified based on histomorphological and epidemiological aspects. Recent data indicates that both variants are defined by specific genetic alterations, and influenced by distinct molecular pathways and particular origins. The fact that CP is an uncommon tumor entity renders studies on large cohorts difficult and exceptional. In order to achieve further insights distinguishing CP variants, we conducted whole genome methylation (450 k array) and microarray-based gene expression studies in addition to CTNNB1 and BRAF mutation analysis using a comprehensive cohort of 80 adaCP and 35 papCP.
Item Description:Gesehen am 11.11.2019
Physical Description:Online Resource
ISSN:2051-5960
DOI:10.1186/s40478-016-0287-6

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