Whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer

The evolution and genetic nature of metastatic lesions is not completely characterized. Here the authors perform a comprehensive whole-genome study of colorectal metastases in comparison to matched primary tumors and define a multistage progression model and metastasis-specific changes that, in part...

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Main Authors:	Ishaque, Naveed (Author) , Abba, Mohammed L. (Author) , Patil, Nitin (Author) , Paramasivam, Nagarajan (Author) , Hübschmann, Daniel (Author) , Leupold, Jörg (Author) , Balasubramanian, Gnana Prakash (Author) , Kleinheinz, Kortine (Author) , Toprak, Umut (Author) , Hutter, Barbara (Author) , Benner, Axel (Author) , Kerssemakers, Jules (Author) , Marx, Alexander (Author) , Eils, Jürgen (Author) , Schlesner, Matthias (Author) , Eils, Roland (Author) , Brors, Benedikt (Author) , Allgayer, Heike (Author)
Format:	Article (Journal)
Language:	English
Published:	14 November 2018
In:	Nature Communications Year: 2018, Volume: 9
ISSN:	2041-1723
DOI:	10.1038/s41467-018-07041-z
Online Access:	Verlag, Volltext: https://doi.org/10.1038/s41467-018-07041-z Verlag, Volltext: https://www.nature.com/articles/s41467-018-07041-z
Author Notes:	Naveed Ishaque, Mohammed L. Abba, Christine Hauser, Nitin Patil, Nagarajan Paramasivam, Daniel Huebschmann, Jörg Hendrik Leupold, Gnana Prakash Balasubramanian, Kortine Kleinheinz, Umut H. Toprak, Barbara Hutter, Axel Benner, Anna Shavinskaya, Chan Zhou, Zuguang Gu, Jules Kerssemakers, Alexander Marx, Marcin Moniuszko, Miroslaw Kozlowski, Joanna Reszec, Jacek Niklinski, Jürgen Eils, Matthias Schlesner, Roland Eils, Benedikt Brors, Heike Allgayer