Targetable ERBB2 mutations identified in neurofibroma/schwannoma hybrid nerve sheath tumors

Neurofibroma/schwannoma hybrid nerve sheath tumors (N/S HNSTs) are neoplasms associated with larger nerves that occur sporadically and in the context of schwannomatosis or neurofibromatosis type 2 or 1. Clinical management of N/S HNST is challenging, especially for large tumors, and established syst...

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Main Authors:	Ronellenfitsch, Michael Wilfried (Author) , Harter, Patrick N. (Author) , Kirchner, Martina (Author) , Heining, Christoph (Author) , Hutter, Barbara (Author) , Gieldon, Laura (Author) , Schittenhelm, Jens Florian (Author) , Schuhmann, Martin U. (Author) , Tatagiba, Marcos (Author) , Marquardt, Gerhard (Author) , Wagner, Marlies (Author) , Endris, Volker (Author) , Brandts, Christian H. (Author) , Mautner, Victor-Felix (Author) , Schröck, Evelin (Author) , Weichert, Wilko (Author) , Brors, Benedikt (Author) , Deimling, Andreas von (Author) , Mittelbronn, Michel (Author) , Steinbach, Joachim P. (Author) , Reuss, David (Author) , Glimm, Hanno (Author) , Stenzinger, Albrecht (Author) , Fröhling, Stefan (Author)
Format:	Article (Journal)
Language:	English
Published:	February 4, 2020
In:	The journal of clinical investigation Year: 2020, Volume: 130, Issue: 5, Pages: 2488-2495
ISSN:	1558-8238
DOI:	10.1172/JCI130787
Online Access:	Resolving-System, Volltext: https://doi.org/10.1172/JCI130787 Verlag: https://www.jci.org/articles/view/130787
Author Notes:	Michael W. Ronellenfitsch, Patrick N. Harter, Martina Kirchner, Christoph Heining, Barbara Hutter, Laura Gieldon, Jens Schittenhelm, Martin U. Schuhmann, Marcos Tatagiba, Gerhard Marquardt, Marlies Wagner, Volker Endris, Christian H. Brandts, Victor-Felix Mautner, Evelin Schröck, Wilko Weichert, Benedikt Brors, Andreas von Deimling, Michel Mittelbronn, Joachim P. Steinbach, David E. Reuss, Hanno Glimm, Albrecht Stenzinger, and Stefan Fröhling