Epistatic effect of TLR3 and cGAS-STING-IKKε-TBK1-IFN signaling variants on colorectal cancer risk

The TLR3/cGAS-STING-IFN signaling has recently been reported to be disturbed in colorectal cancer due to deregulated expression of the genes involved. Our study aimed to investigate the influence of potential regulatory variants in these genes on the risk of sporadic colorectal cancer (CRC) in a Cze...

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Hauptverfasser: Catalano, Calogerina (VerfasserIn) , Filho, Miguel Inacio da Silva (VerfasserIn) , Frank, Christoph (VerfasserIn) , Lu, Shun (VerfasserIn) , Jiraskova, Katerina (VerfasserIn) , Vymetalkova, Veronika (VerfasserIn) , Levy, Miroslav (VerfasserIn) , Liska, Vaclav (VerfasserIn) , Vycital, Ondrej (VerfasserIn) , Naccarati, Alessio (VerfasserIn) , Vodickova, Ludmila (VerfasserIn) , Hemminki, Kari (VerfasserIn) , Vodicka, Pavel (VerfasserIn) , Weber, Alexander N. R. (VerfasserIn) , Försti, Asta (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2020
In: Cancer medicine
Year: 2019, Jahrgang: 9, Heft: 4, Pages: 1473-1484
ISSN:2045-7634
DOI:10.1002/cam4.2804
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1002/cam4.2804
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/cam4.2804
Volltext
Verfasserangaben:Calogerina Catalano, Miguel Inacio da Silva Filho, Christoph Frank, Shun Lu, Katerina Jiraskova, Veronika Vymetalkova, Miroslav Levy, Vaclav Liska, Ondrej Vycital, Alessio Naccarati, Ludmila Vodickova, Kari Hemminki, Pavel Vodicka, Alexander N.R. Weber, Asta Försti
Beschreibung
Zusammenfassung:The TLR3/cGAS-STING-IFN signaling has recently been reported to be disturbed in colorectal cancer due to deregulated expression of the genes involved. Our study aimed to investigate the influence of potential regulatory variants in these genes on the risk of sporadic colorectal cancer (CRC) in a Czech cohort of 1424 CRC patients and 1114 healthy controls.
Beschreibung:First published: 23 December 2019
Gesehen am 02.04.2020
Beschreibung:Online Resource
ISSN:2045-7634
DOI:10.1002/cam4.2804