Cover Image

Evidence that hepatitis B virus replication in mouse cells is limited by the lack of a host cell dependency factor

Hepatitis B virus (HBV) is a major human pathogen restricted to hepatocytes. Expression of the specific receptor human sodium taurocholate cotransporting polypeptide (hNTCP) in mouse hepatocytes renders them susceptible to hepatitis delta virus (HDV), a satellite of HBV; however, HBV remains restric...

Full description

Saved in:
Bibliographic Details
Main Authors: Lempp, Florian A. (Author) , Mutz, Pascal (Author) , Lipps, Christoph (Author) , Wirth, Dagmar (Author) , Bartenschlager, Ralf (Author) , Urban, Stephan (Author)
Format: Article (Journal)
Language:English
Published: 2016
In: Journal of hepatology
Year: 2015, Volume: 64, Issue: 3, Pages: 556-564
ISSN:1600-0641
DOI:10.1016/j.jhep.2015.10.030
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jhep.2015.10.030
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0168827815007369
Get full text
Author Notes:Florian A. Lempp, Pascal Mutz, Christoph Lipps, Dagmar Wirth, Ralf Bartenschlager, Stephan Urban
Description
Summary:Hepatitis B virus (HBV) is a major human pathogen restricted to hepatocytes. Expression of the specific receptor human sodium taurocholate cotransporting polypeptide (hNTCP) in mouse hepatocytes renders them susceptible to hepatitis delta virus (HDV), a satellite of HBV; however, HBV remains restricted at an early stage of replication. This study aims at clarifying whether this restriction is caused by the lack of a dependency factor or the activity of a restriction factor.
Item Description:Available online 11 November 2015
Gesehen am 17.06.2020
Physical Description:Online Resource
ISSN:1600-0641
DOI:10.1016/j.jhep.2015.10.030

Similar Items