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Evidence that hepatitis B virus replication in mouse cells is limited by the lack of a host cell dependency factor

Hepatitis B virus (HBV) is a major human pathogen restricted to hepatocytes. Expression of the specific receptor human sodium taurocholate cotransporting polypeptide (hNTCP) in mouse hepatocytes renders them susceptible to hepatitis delta virus (HDV), a satellite of HBV; however, HBV remains restric...

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Bibliographische Detailangaben
Hauptverfasser: Lempp, Florian A. (VerfasserIn) , Mutz, Pascal (VerfasserIn) , Lipps, Christoph (VerfasserIn) , Wirth, Dagmar (VerfasserIn) , Bartenschlager, Ralf (VerfasserIn) , Urban, Stephan (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2016
In: Journal of hepatology
Year: 2015, Jahrgang: 64, Heft: 3, Pages: 556-564
ISSN:1600-0641
DOI:10.1016/j.jhep.2015.10.030
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jhep.2015.10.030
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0168827815007369
Volltext
Verfasserangaben:Florian A. Lempp, Pascal Mutz, Christoph Lipps, Dagmar Wirth, Ralf Bartenschlager, Stephan Urban
Beschreibung
Zusammenfassung:Hepatitis B virus (HBV) is a major human pathogen restricted to hepatocytes. Expression of the specific receptor human sodium taurocholate cotransporting polypeptide (hNTCP) in mouse hepatocytes renders them susceptible to hepatitis delta virus (HDV), a satellite of HBV; however, HBV remains restricted at an early stage of replication. This study aims at clarifying whether this restriction is caused by the lack of a dependency factor or the activity of a restriction factor.
Beschreibung:Available online 11 November 2015
Gesehen am 17.06.2020
Beschreibung:Online Resource
ISSN:1600-0641
DOI:10.1016/j.jhep.2015.10.030

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