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A physiologically based pharmacokinetic model of voriconazole integrating time-dependent inhibition of CYP3A4, genetic polymorphisms of CYP2C19 and predictions of drug-drug interactions

Voriconazole, a first-line antifungal drug, exhibits nonlinear pharmacokinetics (PK), together with large interindividual variability but a narrow therapeutic range, and markedly inhibits cytochrome P450 (CYP) 3A4 in vivo. This causes difficulties in selecting appropriate dosing regimens of voricona...

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Main Authors: Li, Xia (Author) , Frechen, Sebastian (Author) , Moj, Daniel (Author) , Lehr, Thorsten (Author) , Taubert, Max (Author) , Hsin, Chih-hsuan (Author) , Mikus, Gerd (Author) , Neuvonen, Pertti J. (Author) , Olkkola, Klaus T. (Author) , Saari, Teijo I. (Author) , Fuhr, Uwe (Author)
Format: Article (Journal)
Language:English
Published: 2020
In: Clinical pharmacokinetics
Year: 2019, Volume: 59, Issue: 6, Pages: 781-808
ISSN:1179-1926
DOI:10.1007/s40262-019-00856-z
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s40262-019-00856-z
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Author Notes:Xia Li, Sebastian Frechen, Daniel Moj, Thorsten Lehr, Max Taubert, Chih-hsuan Hsin, Gerd Mikus, Pertti J. Neuvonen, Klaus T. Olkkola, Teijo I. Saari, Uwe Fuhr
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Summary:Voriconazole, a first-line antifungal drug, exhibits nonlinear pharmacokinetics (PK), together with large interindividual variability but a narrow therapeutic range, and markedly inhibits cytochrome P450 (CYP) 3A4 in vivo. This causes difficulties in selecting appropriate dosing regimens of voriconazole and coadministered CYP3A4 substrates.
Item Description:Gesehen am 23.07.2020
First published: 19 December 2019
Physical Description:Online Resource
ISSN:1179-1926
DOI:10.1007/s40262-019-00856-z

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