Search Results - Lehr, Thorsten
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Efficacy and safety of asunercept, a CD95L-selective inhibitor, in hospitalised patients with moderate-to-severe COVID-19: ASUNCTIS, a multicentre, randomised, open-label, controll... by Ruiz Seco, Maria Pilar (Author) , Paño Pardo, José Ramón (Author) , Schoergenhofer, Christian (Author) , Dings, Christiane (Author) , Lehr, Thorsten (Author) , Herth, Felix (Author) , Krendyukov, Andriy (Author) , Straub, Carola (Author) , Kappler, Martin (Author) , Jilma, Bernd (Author) , Fricke, Harald (Author) , Pardo, Julian (Author) , de Miguel, Diego (Author) , Thiemann, Meinolf (Author) , Bergmann, Michael (Author) , Walczak, Henning (Author) , Hoeger, Thomas (Author) ,
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A physiologically based pharmacokinetic model of ketoconazole and its metabolites as drug-drug interaction perpetrators by Marok, Fatima (Author) , Wojtyniak, Jan-Georg (Author) , Fuhr, Laura Maria (Author) , Selzer, Dominik (Author) , Schwab, Matthias (Author) , Weiß, Johanna (Author) , Haefeli, Walter E. (Author) , Lehr, Thorsten (Author) ,
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Does the circulating ketoconazole metabolite N-deacetyl ketoconazole contribute to the drug-drug interaction potential of the parent compound? by Weiß, Johanna (Author) , Foerster, Kathrin (Author) , Weber, Maria (Author) , Burhenne, Jürgen (Author) , Mikus, Gerd (Author) , Lehr, Thorsten (Author) , Haefeli, Walter E. (Author) ,
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A physiologically based pharmacokinetic model of voriconazole integrating time-dependent inhibition of CYP3A4, genetic polymorphisms of CYP2C19 and predictions of drug-drug interac... by Li, Xia (Author) , Frechen, Sebastian (Author) , Moj, Daniel (Author) , Lehr, Thorsten (Author) , Taubert, Max (Author) , Hsin, Chih-hsuan (Author) , Mikus, Gerd (Author) , Neuvonen, Pertti J. (Author) , Olkkola, Klaus T. (Author) , Saari, Teijo I. (Author) , Fuhr, Uwe (Author) ,
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A mechanistic, enantioselective, physiologically based pharmacokinetic model of verapamil and norverapamil, built and evaluated for drug-drug interaction studies by Hanke, Nina (Author) , Türk, Denise (Author) , Selzer, Dominik (Author) , Wiebe, Sabrina (Author) , Fernandez, Éric (Author) , Stopfer, Peter (Author) , Nock, Valerie Christine (Author) , Lehr, Thorsten (Author) ,
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Related Subjects
cytochrome P450 3A4 (CYP3A4)
physiologically based pharmacokinetic (PBPK) modeling
Apoptosis
Asunercept
CD95L (FasL)
COVID-19
CYP
Death ligand blockade
Drug transporters
Drug-drug interaction
Ketoconazole
Lymphocytopenia
N-deacetyl ketoconazole
P-glycoprotein (P-gp)
P-glycoprotein (Pgp)
Phase 2 clinical trial
UPLC-MS/MS
drug-drug interaction
drug-drug interactions (DDIs)
drug-food interaction
ketoconazole
mechanism-based inactivation (MBI)
metabolites
model-informed drug discovery and development (MID3)
non-competitive inhibition
norverapamil
reversible inhibition
verapamil