Netrin-1 expression is an independent prognostic factor for poor patient survival in brain metastases

The multifunctional molecule netrin-1 is upregulated in various malignancies and has recently been presented as a major general player in tumorigenesis leading to tumor progression and maintenance in various animal models. However, there is still a lack of clinico-epidemiological data related to net...

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Main Authors: Harter, Patrick Nikolaus (Author) , Zinke, Jenny (Author) , Scholz, Alexander (Author) , Tichy, Julia Frederike (Author) , Zachskorn, Cornelia (Author) , Kvasnicka, Hans M. (Author) , Goeppert, Benjamin (Author) , Delloye-Bourgeois, Céline (Author) , Hattingen, Elke (Author) , Senft, Christian (Author) , Steinbach, Joachim Peter (Author) , Plate, Karl (Author) , Mehlen, Patrick (Author) , Schulte, Dorothea (Author) , Mittelbronn, Michel Guy André (Author)
Format: Article (Journal)
Language:English
Published: March 19, 2014
In: PLOS ONE
Year: 2014, Volume: 9, Issue: 3
ISSN:1932-6203
DOI:10.1371/journal.pone.0092311
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1371/journal.pone.0092311
Verlag, lizenzpflichtig, Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0092311
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Author Notes:Patrick N. Harter, Jenny Zinke, Alexander Scholz, Julia Tichy, Cornelia Zachskorn, Hans M. Kvasnicka, Benjamin Goeppert, Céline Delloye-Bourgeois, Elke Hattingen, Christian Senft, Joachim P. Steinbach, Karl H. Plate, Patrick Mehlen, Dorothea Schulte, Michel Mittelbronn
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Summary:The multifunctional molecule netrin-1 is upregulated in various malignancies and has recently been presented as a major general player in tumorigenesis leading to tumor progression and maintenance in various animal models. However, there is still a lack of clinico-epidemiological data related to netrin-1 expression. Therefore, the aim of our study was to elucidate the association of netrin-1 expression and patient survival in brain metastases since those constitute one of the most limiting factors for patient prognosis.
Item Description:Gesehen am 25.09.2020
Physical Description:Online Resource
ISSN:1932-6203
DOI:10.1371/journal.pone.0092311