Cover Image

The landscape of chromothripsis across adult cancer types

Chromothripsis is a recently identified mutational phenomenon, by which a presumably single catastrophic event generates extensive genomic rearrangements of one or a few chromosome(s). Considered as an early event in tumour development, this form of genome instability plays a prominent role in tumou...

Full description

Saved in:
Bibliographic Details
Main Authors: Voronina, Natalia (Author) , Wong, John K. L. (Author) , Hübschmann, Daniel (Author) , Hlevnjak, Mario (Author) , Uhrig, Sebastian (Author) , Heilig, Christoph E. (Author) , Horak, Peter (Author) , Kreutzfeldt, Simon (Author) , Mock, Andreas (Author) , Stenzinger, Albrecht (Author) , Hutter, Barbara (Author) , Fröhlich, Martina (Author) , Brors, Benedikt (Author) , Jahn, Arne (Author) , Klink, Barbara (Author) , Gieldon, Laura (Author) , Sieverling, Lina Katharine (Author) , Feuerbach, Lars (Author) , Chudasama, Priya (Author) , Beck, Katja (Author) , Kroiss, Matthias (Author) , Heining, Christoph (Author) , Möhrmann, Lino (Author) , Fischer, Andrea (Author) , Schröck, Evelin (Author) , Glimm, Hanno (Author) , Zapatka, Marc (Author) , Lichter, Peter (Author) , Fröhling, Stefan (Author) , Ernst, Aurélie (Author)
Format: Article (Journal)
Language:English
Published: 08 May 2020
In: Nature Communications
Year: 2020, Volume: 11
ISSN:2041-1723
DOI:10.1038/s41467-020-16134-7
Online Access:Verlag, lizenzpflichtig, Volltext: https://dx.doi.org/10.1038/s41467-020-16134-7
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41467-020-16134-7
Get full text
Author Notes:Natalia Voronina, John K.L. Wong, Daniel Hübschmann, Mario Hlevnjak, Sebastian Uhrig, Christoph E. Heilig, Peter Horak, Simon Kreutzfeldt, Andreas Mock, Albrecht Stenzinger, Barbara Hutter, Martina Fröhlich, Benedikt Brors, Arne Jahn, Barbara Klink, Laura Gieldon, Lina Sieverling, Lars Feuerbach, Priya Chudasama, Katja Beck, Matthias Kroiss, Christoph Heining, Lino Möhrmann, Andrea Fischer, Evelin Schröck, Hanno Glimm, Marc Zapatka, Peter Lichter, Stefan Fröhling & Aurélie Ernst
Description
Summary:Chromothripsis is a recently identified mutational phenomenon, by which a presumably single catastrophic event generates extensive genomic rearrangements of one or a few chromosome(s). Considered as an early event in tumour development, this form of genome instability plays a prominent role in tumour onset. Chromothripsis prevalence might have been underestimated when using low-resolution methods, and pan-cancer studies based on sequencing are rare. Here we analyse chromothripsis in 28 tumour types covering all major adult cancers (634 tumours, 316 whole-genome and 318 whole-exome sequences). We show that chromothripsis affects a substantial proportion of human cancers, with a prevalence of 49% across all cases. Chromothripsis generates entity-specific genomic alterations driving tumour development, including clinically relevant druggable fusions. Chromothripsis is linked with specific telomere patterns and univocal mutational signatures in distinct tumour entities. Longitudinal analysis of chromothriptic patterns in 24 matched tumour pairs reveals insights in the clonal evolution of tumours with chromothripsis.
Item Description:Gesehen am 13.10.2020
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-020-16134-7

Similar Items