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The majority of β-catenin mutations in colorectal cancer is homozygous

β-catenin activation plays a crucial role for tumourigenesis in the large intestine but except for Lynch syndrome (LS) associated cancers stabilizing mutations of β-catenin gene (CTNNB1) are rare in colorectal cancer (CRC). Previous animal studies provide an explanation for this observation. They sh...

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Main Authors: Arnold, Alexander (Author) , Tronser, Moritz (Author) , Sers, Christine (Author) , Ahadova, Aysel (Author) , Endris, Volker (Author) , Mamlouk, Soulafa (Author) , Horst, David (Author) , Möbs, Markus (Author) , Bischoff, Philip (Author) , Kloor, Matthias (Author) , Bläker, Hendrik (Author)
Format: Article (Journal)
Language:English
Published: 28 October 2020
In: BMC cancer
Year: 2020, Volume: 20, Pages: 1-10
ISSN:1471-2407
DOI:10.1186/s12885-020-07537-2
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12885-020-07537-2
Verlag, kostenfrei, Volltext: https://bmccancer.biomedcentral.com/articles/10.1186/s12885-020-07537-2
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Author Notes:Alexander Arnold, Moritz Tronser, Christine Sers, Aysel Ahadova, Volker Endris, Soulafa Mamlouk, David Horst, Markus Möbs, Philip Bischoff, Matthias Kloor, and Hendrik Bläker
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Summary:β-catenin activation plays a crucial role for tumourigenesis in the large intestine but except for Lynch syndrome (LS) associated cancers stabilizing mutations of β-catenin gene (CTNNB1) are rare in colorectal cancer (CRC). Previous animal studies provide an explanation for this observation. They showed that CTNNB1 mutations induced transformation in the colon only when CTNNB1 was homozygously mutated or when membranous β-catenin binding was hampered by E-cadherin haploinsufficiency. We were interested, if these mechanisms are also found in human CTNNB1 mutated CRCs.
Item Description:Gesehen am 28.10.2024
Physical Description:Online Resource
ISSN:1471-2407
DOI:10.1186/s12885-020-07537-2

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