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The majority of β-catenin mutations in colorectal cancer is homozygous

β-catenin activation plays a crucial role for tumourigenesis in the large intestine but except for Lynch syndrome (LS) associated cancers stabilizing mutations of β-catenin gene (CTNNB1) are rare in colorectal cancer (CRC). Previous animal studies provide an explanation for this observation. They sh...

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Main Authors: Arnold, Alexander (Author) , Tronser, Moritz (Author) , Sers, Christine (Author) , Ahadova, Aysel (Author) , Endris, Volker (Author) , Mamlouk, Soulafa (Author) , Horst, David (Author) , Möbs, Markus (Author) , Bischoff, Philip (Author) , Kloor, Matthias (Author) , Bläker, Hendrik (Author)
Format: Article (Journal)
Language:English
Published: 28 October 2020
In: BMC cancer
Year: 2020, Volume: 20, Pages: 1-10
ISSN:1471-2407
DOI:10.1186/s12885-020-07537-2
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12885-020-07537-2
Verlag, kostenfrei, Volltext: https://bmccancer.biomedcentral.com/articles/10.1186/s12885-020-07537-2
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Author Notes:Alexander Arnold, Moritz Tronser, Christine Sers, Aysel Ahadova, Volker Endris, Soulafa Mamlouk, David Horst, Markus Möbs, Philip Bischoff, Matthias Kloor, and Hendrik Bläker

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