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PTH pulsatility but not calcium sensitivity is restored after total parathyroidectomy with heterotopic autotransplantation

In healthy humans, parathyroid hormone (PTH) is secreted via basal mode with superimposed oscillatory bursts every 8 to 12 min. Amplitude and frequency changes mediate the instantaneous response of the parathyroids to changes in ambient Ca2+ concentrations. The parathyroid gland tetrad may be synchr...

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Main Authors: Schmitt, Claus P. (Author) , Wenning, Swee (Author) , Mehls, Otto (Author) , Veldhuis, Johannes D. (Author) , Lehnert, Thomas (Author) , Ritz, Eberhard (Author) , Schaefer, Franz (Author)
Format: Article (Journal)
Language:English
Published: February 1, 2003
In: Journal of the American Society of Nephrology
Year: 2003, Volume: 14, Issue: 2, Pages: 407-414
ISSN:1533-3450
DOI:10.1097/01.ASN.0000043905.35268.86
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1097/01.ASN.0000043905.35268.86
Verlag, lizenzpflichtig, Volltext: https://jasn.asnjournals.org/content/14/2/407
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Author Notes:Claus P. Schmitt, Swee Löcken, Otto Mehls, Johannes D. Veldhuis, Thomas Lehnert, Eberhard Ritz, and Franz Schaefer
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Summary:In healthy humans, parathyroid hormone (PTH) is secreted via basal mode with superimposed oscillatory bursts every 8 to 12 min. Amplitude and frequency changes mediate the instantaneous response of the parathyroids to changes in ambient Ca2+ concentrations. The parathyroid gland tetrad may be synchronized by autonomic innervation. This study investigated the effect of total parathyroidectomy and heterotopic autotransplantation of parathyroid tissue (PTX) on PTH secretion patterns in nine patients with end-stage renal disease.
Item Description:Gesehen am 15.01.2021
Physical Description:Online Resource
ISSN:1533-3450
DOI:10.1097/01.ASN.0000043905.35268.86

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