Buchumschlag

PTH pulsatility but not calcium sensitivity is restored after total parathyroidectomy with heterotopic autotransplantation

In healthy humans, parathyroid hormone (PTH) is secreted via basal mode with superimposed oscillatory bursts every 8 to 12 min. Amplitude and frequency changes mediate the instantaneous response of the parathyroids to changes in ambient Ca2+ concentrations. The parathyroid gland tetrad may be synchr...

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Bibliographische Detailangaben
Hauptverfasser: Schmitt, Claus P. (VerfasserIn) , Wenning, Swee (VerfasserIn) , Mehls, Otto (VerfasserIn) , Veldhuis, Johannes D. (VerfasserIn) , Lehnert, Thomas (VerfasserIn) , Ritz, Eberhard (VerfasserIn) , Schaefer, Franz (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: February 1, 2003
In: Journal of the American Society of Nephrology
Year: 2003, Jahrgang: 14, Heft: 2, Pages: 407-414
ISSN:1533-3450
DOI:10.1097/01.ASN.0000043905.35268.86
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1097/01.ASN.0000043905.35268.86
Verlag, lizenzpflichtig, Volltext: https://jasn.asnjournals.org/content/14/2/407
Volltext
Verfasserangaben:Claus P. Schmitt, Swee Löcken, Otto Mehls, Johannes D. Veldhuis, Thomas Lehnert, Eberhard Ritz, and Franz Schaefer
Beschreibung
Zusammenfassung:In healthy humans, parathyroid hormone (PTH) is secreted via basal mode with superimposed oscillatory bursts every 8 to 12 min. Amplitude and frequency changes mediate the instantaneous response of the parathyroids to changes in ambient Ca2+ concentrations. The parathyroid gland tetrad may be synchronized by autonomic innervation. This study investigated the effect of total parathyroidectomy and heterotopic autotransplantation of parathyroid tissue (PTX) on PTH secretion patterns in nine patients with end-stage renal disease.
Beschreibung:Gesehen am 15.01.2021
Beschreibung:Online Resource
ISSN:1533-3450
DOI:10.1097/01.ASN.0000043905.35268.86

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