Analysis of isoaspartate in peptides by electrospray tandem mass spectrometry

In view of the significance of Asn deamidation and Asp isomerization to isoAsp at certain sites for protein aging and turnover, it was desirable to challenge the extreme analytical power of electrospray tandem mass spectrometry (ESI‐MS/MS) for the possibility of a site‐specific detection of this pos...

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Bibliographic Details
Main Authors: Lehmann, Wolf-Dieter (Author) , Pipkorn, Rüdiger (Author) , Bossemeyer, Dirk (Author) , Kinzel, Volker (Author)
Format: Article (Journal)
Language:English
Published: 31 December 2008
In: Protein science
Year: 2000, Volume: 9, Issue: 11, Pages: 2260-2268
ISSN:1469-896X
DOI:10.1110/ps.9.11.2260
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1110/ps.9.11.2260
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/10.1110/ps.9.11.2260
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Author Notes:Wolf D. Lehmann, Andreas Schlosser, Gerhard Erben, Rüdiger Pipkorn, Dirk Bossemeyer, and Volker Kinzel
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Summary:In view of the significance of Asn deamidation and Asp isomerization to isoAsp at certain sites for protein aging and turnover, it was desirable to challenge the extreme analytical power of electrospray tandem mass spectrometry (ESI‐MS/MS) for the possibility of a site‐specific detection of this posttranslational modification.
Item Description:First published online: 31 December 2008
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Physical Description:Online Resource
ISSN:1469-896X
DOI:10.1110/ps.9.11.2260