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Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo

Recent epidemiological studies show a strong reduction in the - incidence of Alzheimer's disease in patients treated with - cholesterol-lowering statins. Moreover, elevated Aβ42 levels and the - ɛ4 allele of the lipid-carrier apolipoprotein E are regarded as risk - factors for sporadic and...

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Hauptverfasser: Faßbender, Klaus (VerfasserIn) , Simons, M. (VerfasserIn) , Bergmann, Carina (VerfasserIn) , Stroick, Mark Gregor (VerfasserIn) , Lütjohann, D. (VerfasserIn) , Keller, P. (VerfasserIn) , Runz, Heiko (VerfasserIn) , Kühl, Sandra (VerfasserIn) , Bertsch, Thomas (VerfasserIn) , Bergmann, K. von (VerfasserIn) , Hennerici, Michael G. (VerfasserIn) , Beyreuther, Konrad (VerfasserIn) , Hartmann, Tobias (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: [May 8, 2001]
In: Proceedings of the National Academy of Sciences of the United States of America
Year: 2001, Jahrgang: 98, Heft: 10, Pages: 5856-5861
ISSN:1091-6490
DOI:10.1073/pnas.081620098
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1073/pnas.081620098
Verlag, lizenzpflichtig, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC33303/
Volltext
Verfasserangaben:K. Fassbender, M. Simons, C. Bergmann, M. Stroick, D. Lütjohann, P. Keller, H. Runz, S. Kühl, T. Bertsch, K. von Bergmann, M. Hennerici, K. Beyreuther, and T. Hartmann
Beschreibung
Zusammenfassung:Recent epidemiological studies show a strong reduction in the - incidence of Alzheimer's disease in patients treated with - cholesterol-lowering statins. Moreover, elevated Aβ42 levels and the - ɛ4 allele of the lipid-carrier apolipoprotein E are regarded as risk - factors for sporadic and familial Alzheimer's disease. Here we - demonstrate that the widely used cholesterol-lowering drugs simvastatin - and lovastatin reduce intracellular and extracellular levels of Aβ42 - and Aβ40 peptides in primary cultures of hippocampal neurons and - mixed cortical neurons. Likewise, guinea pigs treated with high doses - of simvastatin showed a strong and reversible reduction of cerebral - Aβ42 and Aβ40 levels in the cerebrospinal fluid and brain - homogenate. These results suggest that lipids are playing an important - role in the development of Alzheimer's disease. Lowered levels of - Aβ42 may provide the mechanism for the observed reduced incidence of - dementia in statin-treated patients and may open up avenues for - therapeutic interventions.
Beschreibung:Gesehen am 31.03.2021
Beschreibung:Online Resource
ISSN:1091-6490
DOI:10.1073/pnas.081620098

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