Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis

Background & Aims - In chronic liver diseases, inflammation induces oxidative stress and thus may contribute to the progression of liver injury, fibrosis, and carcinogenesis. The KEAP1/NRF2 axis is a major regulator of cellular redox balance. In the present study, we investigated whether the KEA...

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Main Authors: Mohs, Antje (Author) , Otto, Tobias (Author) , Schneider, Kai Markus (Author) , Peltzer, Mona (Author) , Boekschoten, Mark (Author) , Holland, Christian H. (Author) , Hudert, Christian A. (Author) , Kalveram, Laura (Author) , Wiegand, Susanna (Author) , Sáez Rodríguez, Julio (Author) , Longerich, Thomas (Author) , Hengstler, Jan G. (Author) , Trautwein, Christian (Author)
Format: Article (Journal)
Language:English
Published: 2021
In: Journal of hepatology
Year: 2021, Volume: 74, Issue: 3, Pages: 638-648
ISSN:1600-0641
DOI:10.1016/j.jhep.2020.09.037
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jhep.2020.09.037
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0168827820336953
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Author Notes:Antje Mohs, Tobias Otto, Kai Markus Schneider, Mona Peltzer, Mark Boekschoten, Christian H. Holland, Christian A. Hudert, Laura Kalveram, Susanna Wiegand, Julio Saez-Rodriguez, Thomas Longerich, Jan G. Hengstler, Christian Trautwein
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