Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis
Background & Aims - In chronic liver diseases, inflammation induces oxidative stress and thus may contribute to the progression of liver injury, fibrosis, and carcinogenesis. The KEAP1/NRF2 axis is a major regulator of cellular redox balance. In the present study, we investigated whether the KEA...
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| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2021
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| In: |
Journal of hepatology
Year: 2021, Volume: 74, Issue: 3, Pages: 638-648 |
| ISSN: | 1600-0641 |
| DOI: | 10.1016/j.jhep.2020.09.037 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jhep.2020.09.037 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0168827820336953 |
| Author Notes: | Antje Mohs, Tobias Otto, Kai Markus Schneider, Mona Peltzer, Mark Boekschoten, Christian H. Holland, Christian A. Hudert, Laura Kalveram, Susanna Wiegand, Julio Saez-Rodriguez, Thomas Longerich, Jan G. Hengstler, Christian Trautwein |
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