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A novel low-risk germline variant in the SH2 domain of the SRC gene affects multiple pathways in familial colorectal cancer

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Colorectal cancer (CRC) shows one of the largest proportions of familial cases among different malignancies, but only 5-10% of all CRC cases are linked to mutations in established predisposition genes. Thus, familial CRC constitutes a promising target for the identification of novel, high- to modera...

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Main Authors: Skopelitou, Diamanto (Author) , Miao, Beiping (Author) , Srivastava, Aayushi (Author) , Kumar, Abhishek (Author) , Kuświk, Magdalena (Author) , Dymerska, Dagmara (Author) , Paramasivam, Nagarajan (Author) , Schlesner, Matthias (Author) , Lubiński, Jan (Author) , Hemminki, Kari (Author) , Försti, Asta (Author) , Bandapalli, Obul Reddy (Author)
Format: Article (Journal)
Language:English
Published: 1 April 2021
In: Journal of Personalized Medicine
Year: 2021, Volume: 11, Issue: 4, Pages: 1-15
ISSN:2075-4426
DOI:10.3390/jpm11040262
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/jpm11040262
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2075-4426/11/4/262
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Author Notes:Diamanto Skopelitou, Beiping Miao, Aayushi Srivastava, Abhishek Kumar, Magdalena Kuświk, Dagmara Dymerska, Nagarajan Paramasivam, Matthias Schlesner, Jan Lubiński, Kari Hemminki, Asta Försti, Obul Reddy Bandapalli
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Differences in global gene expression in melanoma cell lines with and without homozygous deletion of the CDKN2A locus genes by Blöthner, Sandra (Author) , Hemminki, Kari (Author) , Chen, Bowang (Author) , Ugurel, Selma (Author) , Schadendorf, Dirk (Author) , Kumar, Rajiv (Author) ,


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