Cover Image

Mutation-specific pathophysiological mechanisms define different neurodevelopmental disorders associated with SATB1 dysfunction

Whereas large-scale statistical analyses can robustly identify disease-gene relationships, they do not accurately capture genotype-phenotype correlations or disease mechanisms. We use multiple lines of independent evidence to show that different variant types in a single gene, SATB1, cause clinicall...

Full description

Saved in:
Bibliographic Details
Main Authors: Hoed, Joery den (Author) , de Boer, Elke (Author) , Voisin, Norine (Author) , Dingemans, Alexander J. M. (Author) , Guex, Nicolas (Author) , Wiel, Laurens (Author) , Nellaker, Christoffer (Author) , Amudhavalli, Shivarajan M. (Author) , Banka, Siddharth (Author) , Bena, Frederique S. (Author) , Ben-Zeev, Bruria (Author) , Bonagura, Vincent R. (Author) , Bruel, Ange-Line (Author) , Brunet, Theresa (Author) , Brunner, Han G. (Author) , Chew, Hui B. (Author) , Chrast, Jacqueline (Author) , Cimbalistienė, Loreta (Author) , Coon, Hilary (Author) , Délot, Emmanuèlle C. (Author) , Démurger, Florence (Author) , Denommé-Pichon, Anne-Sophie (Author) , Depienne, Christel (Author) , Donnai, Dian (Author) , Dyment, David A. (Author) , Elpeleg, Orly (Author) , Faivre, Laurence (Author) , Gilissen, Christian (Author) , Granger, Leslie (Author) , Haber, Benjamin (Author) , Hachiya, Yasuo (Author) , Abedi, Yasmin Hamzavi (Author) , Hanebeck, Jennifer (Author) , Hehir-Kwa, Jayne Y. (Author) , Horist, Brooke (Author) , Itai, Toshiyuki (Author) , Kotzaeridou, Urania (Author) , Orec, Laura (Author)
Format: Article (Journal)
Language:English
Published: 28 January 2021
In: The American journal of human genetics
Year: 2021, Volume: 108, Issue: 2, Pages: 346-356
ISSN:1537-6605
DOI:10.1016/j.ajhg.2021.01.007
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ajhg.2021.01.007
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0002929721000070
Get full text
Author Notes:Joery den Hoed, Elke de Boer, Norine Voisin, Alexander J.M. Dingemans, Nicolas Guex, Laurens Wiel, Christoffer Nellaker, Shivarajan M. Amudhavalli, Siddharth Banka, Frederique S. Bena, Bruria Ben-Zeev, Vincent R. Bonagura, Ange-Line Bruel, Theresa Brunet, Han G. Brunner, Hui B. Chew, Jacqueline Chrast, Loreta Cimbalistienė, Hilary Coon, Emmanuèlle C. Délot, Florence Démurger, Anne-Sophie Denommé-Pichon, Christel Depienne, Dian Donnai, David A. Dyment, Orly Elpeleg, Laurence Faivre, Christian Gilissen, Leslie Granger, Benjamin Haber, Yasuo Hachiya, Yasmin Hamzavi Abedi, Jennifer Hanebeck, Jayne Y. Hehir-Kwa, Brooke Horist, Toshiyuki Itai, Adam Jackson, Rosalyn Jewell, Kelly L. Jones, Shelagh Joss, Hirofumi Kashii, Mitsuhiro Kato, Anja A. Kattentidt-Mouravieva, Fernando Kok, Urania Kotzaeridou, Vidya Krishnamurthy, Vaidutis Kučinskas, Alma Kuechler, Alinoë Lavillaureix, Pengfei Liu, Linda Manwaring, Naomichi Matsumoto, Benoît Mazel, Kirsty McWalter, Vardiella Meiner, Mohamad A. Mikati, Satoko Miyatake, Takeshi Mizuguchi, Lip H. Moey, Shehla Mohammed, Hagar Mor-Shaked, Hayley Mountford, Ruth Newbury-Ecob, Sylvie Odent, Laura Orec, Matthew Osmond, Timothy B. Palculict, Michael Parker, Andrea K. Petersen, Rolph Pfundt, Eglė Preikšaitienė, Kelly Radtke, Emmanuelle Ranza, Jill A. Rosenfeld, Teresa Santiago-Sim, Caitlin Schwager, Margje Sinnema, Lot Snijders Blok, Rebecca C. Spillmann, Alexander P.A. Stegmann, Isabelle Thiffault, Linh Tran, Adi Vaknin-Dembinsky, Juliana H. Vedovato-dos-Santos, Samantha A. Schrier Vergano, Eric Vilain, Antonio Vitobello, Matias Wagner, Androu Waheeb, Marcia Willing, Britton Zuccarelli, Usha Kini, Dianne F. Newbury, Tjitske Kleefstra, Alexandre Reymond, Simon E. Fisher, Lisenka E.L.M. Vissers

MARC

LEADER 00000caa a22000002c 4500
001 1764273338
003 DE-627
005 20230426140750.0
007 cr uuu---uuuuu
008 210724s2021 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.ajhg.2021.01.007  |2 doi 
035 |a (DE-627)1764273338 
035 |a (DE-599)KXP1764273338 
035 |a (OCoLC)1341419813 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Hoed, Joery den  |e VerfasserIn  |0 (DE-588)1237217873  |0 (DE-627)1763141438  |4 aut 
245 1 0 |a Mutation-specific pathophysiological mechanisms define different neurodevelopmental disorders associated with SATB1 dysfunction  |c Joery den Hoed, Elke de Boer, Norine Voisin, Alexander J.M. Dingemans, Nicolas Guex, Laurens Wiel, Christoffer Nellaker, Shivarajan M. Amudhavalli, Siddharth Banka, Frederique S. Bena, Bruria Ben-Zeev, Vincent R. Bonagura, Ange-Line Bruel, Theresa Brunet, Han G. Brunner, Hui B. Chew, Jacqueline Chrast, Loreta Cimbalistienė, Hilary Coon, Emmanuèlle C. Délot, Florence Démurger, Anne-Sophie Denommé-Pichon, Christel Depienne, Dian Donnai, David A. Dyment, Orly Elpeleg, Laurence Faivre, Christian Gilissen, Leslie Granger, Benjamin Haber, Yasuo Hachiya, Yasmin Hamzavi Abedi, Jennifer Hanebeck, Jayne Y. Hehir-Kwa, Brooke Horist, Toshiyuki Itai, Adam Jackson, Rosalyn Jewell, Kelly L. Jones, Shelagh Joss, Hirofumi Kashii, Mitsuhiro Kato, Anja A. Kattentidt-Mouravieva, Fernando Kok, Urania Kotzaeridou, Vidya Krishnamurthy, Vaidutis Kučinskas, Alma Kuechler, Alinoë Lavillaureix, Pengfei Liu, Linda Manwaring, Naomichi Matsumoto, Benoît Mazel, Kirsty McWalter, Vardiella Meiner, Mohamad A. Mikati, Satoko Miyatake, Takeshi Mizuguchi, Lip H. Moey, Shehla Mohammed, Hagar Mor-Shaked, Hayley Mountford, Ruth Newbury-Ecob, Sylvie Odent, Laura Orec, Matthew Osmond, Timothy B. Palculict, Michael Parker, Andrea K. Petersen, Rolph Pfundt, Eglė Preikšaitienė, Kelly Radtke, Emmanuelle Ranza, Jill A. Rosenfeld, Teresa Santiago-Sim, Caitlin Schwager, Margje Sinnema, Lot Snijders Blok, Rebecca C. Spillmann, Alexander P.A. Stegmann, Isabelle Thiffault, Linh Tran, Adi Vaknin-Dembinsky, Juliana H. Vedovato-dos-Santos, Samantha A. Schrier Vergano, Eric Vilain, Antonio Vitobello, Matias Wagner, Androu Waheeb, Marcia Willing, Britton Zuccarelli, Usha Kini, Dianne F. Newbury, Tjitske Kleefstra, Alexandre Reymond, Simon E. Fisher, Lisenka E.L.M. Vissers 
264 1 |c 28 January 2021 
300 |a 11 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 24.07.2021 
520 |a Whereas large-scale statistical analyses can robustly identify disease-gene relationships, they do not accurately capture genotype-phenotype correlations or disease mechanisms. We use multiple lines of independent evidence to show that different variant types in a single gene, SATB1, cause clinically overlapping but distinct neurodevelopmental disorders. Clinical evaluation of 42 individuals carrying SATB1 variants identified overt genotype-phenotype relationships, associated with different pathophysiological mechanisms, established by functional assays. Missense variants in the CUT1 and CUT2 DNA-binding domains result in stronger chromatin binding, increased transcriptional repression, and a severe phenotype. In contrast, variants predicted to result in haploinsufficiency are associated with a milder clinical presentation. A similarly mild phenotype is observed for individuals with premature protein truncating variants that escape nonsense-mediated decay, which are transcriptionally active but mislocalized in the cell. Our results suggest that in-depth mutation-specific genotype-phenotype studies are essential to capture full disease complexity and to explain phenotypic variability. 
650 4 |a cell-based functional assays 
650 4 |a de novo variants 
650 4 |a HPO-based analysis 
650 4 |a intellectual disability 
650 4 |a neurodevelopmental disorders 
650 4 |a SATB1 
650 4 |a seizures 
650 4 |a teeth abnormalities 
700 1 |a de Boer, Elke  |e VerfasserIn  |4 aut 
700 1 |a Voisin, Norine  |e VerfasserIn  |4 aut 
700 1 |a Dingemans, Alexander J. M.  |e VerfasserIn  |4 aut 
700 1 |a Guex, Nicolas  |e VerfasserIn  |4 aut 
700 1 |a Wiel, Laurens  |e VerfasserIn  |4 aut 
700 1 |a Nellaker, Christoffer  |e VerfasserIn  |4 aut 
700 1 |a Amudhavalli, Shivarajan M.  |e VerfasserIn  |4 aut 
700 1 |a Banka, Siddharth  |e VerfasserIn  |4 aut 
700 1 |a Bena, Frederique S.  |e VerfasserIn  |4 aut 
700 1 |a Ben-Zeev, Bruria  |e VerfasserIn  |4 aut 
700 1 |a Bonagura, Vincent R.  |e VerfasserIn  |4 aut 
700 1 |a Bruel, Ange-Line  |e VerfasserIn  |4 aut 
700 1 |a Brunet, Theresa  |e VerfasserIn  |4 aut 
700 1 |a Brunner, Han G.  |e VerfasserIn  |4 aut 
700 1 |a Chew, Hui B.  |e VerfasserIn  |4 aut 
700 1 |a Chrast, Jacqueline  |e VerfasserIn  |4 aut 
700 1 |a Cimbalistienė, Loreta  |e VerfasserIn  |4 aut 
700 1 |a Coon, Hilary  |e VerfasserIn  |4 aut 
700 1 |a Délot, Emmanuèlle C.  |e VerfasserIn  |4 aut 
700 1 |a Démurger, Florence  |e VerfasserIn  |4 aut 
700 1 |a Denommé-Pichon, Anne-Sophie  |e VerfasserIn  |4 aut 
700 1 |a Depienne, Christel  |e VerfasserIn  |4 aut 
700 1 |a Donnai, Dian  |e VerfasserIn  |4 aut 
700 1 |a Dyment, David A.  |e VerfasserIn  |4 aut 
700 1 |a Elpeleg, Orly  |e VerfasserIn  |4 aut 
700 1 |a Faivre, Laurence  |e VerfasserIn  |4 aut 
700 1 |a Gilissen, Christian  |e VerfasserIn  |4 aut 
700 1 |a Granger, Leslie  |e VerfasserIn  |4 aut 
700 1 |a Haber, Benjamin  |d 1984-  |e VerfasserIn  |0 (DE-588)1078266212  |0 (DE-627)838220843  |0 (DE-576)450442101  |4 aut 
700 1 |a Hachiya, Yasuo  |e VerfasserIn  |4 aut 
700 1 |a Abedi, Yasmin Hamzavi  |e VerfasserIn  |4 aut 
700 1 |a Hanebeck, Jennifer  |e VerfasserIn  |0 (DE-588)1237589290  |0 (DE-627)1764273273  |4 aut 
700 1 |a Hehir-Kwa, Jayne Y.  |e VerfasserIn  |4 aut 
700 1 |a Horist, Brooke  |e VerfasserIn  |4 aut 
700 1 |a Itai, Toshiyuki  |e VerfasserIn  |4 aut 
700 1 |a Kotzaeridou, Urania  |e VerfasserIn  |0 (DE-588)1070020834  |0 (DE-627)823189996  |0 (DE-576)429699948  |4 aut 
700 1 |a Orec, Laura  |e VerfasserIn  |0 (DE-588)122838925X  |0 (DE-627)1750170000  |4 aut 
773 0 8 |i Enthalten in  |t The American journal of human genetics  |d New York, NY [u.a.] : Cell Press, 1949  |g 108(2021), 2 vom: Feb., Seite 346-356  |w (DE-627)269019014  |w (DE-600)1473813-2  |w (DE-576)077662636  |x 1537-6605  |7 nnas  |a Mutation-specific pathophysiological mechanisms define different neurodevelopmental disorders associated with SATB1 dysfunction 
773 1 8 |g volume:108  |g year:2021  |g number:2  |g month:02  |g pages:346-356  |g extent:11  |a Mutation-specific pathophysiological mechanisms define different neurodevelopmental disorders associated with SATB1 dysfunction 
856 4 0 |u https://doi.org/10.1016/j.ajhg.2021.01.007  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.sciencedirect.com/science/article/pii/S0002929721000070  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20210724 
993 |a Article 
994 |a 2021 
998 |g 122838925X  |a Orec, Laura  |m 122838925X:Orec, Laura  |d 910000  |d 910500  |e 910000PO122838925X  |e 910500PO122838925X  |k 0/910000/  |k 1/910000/910500/  |p 65 
998 |g 1070020834  |a Kotzaeridou, Urania  |m 1070020834:Kotzaeridou, Urania  |d 910000  |d 910500  |e 910000PK1070020834  |e 910500PK1070020834  |k 0/910000/  |k 1/910000/910500/  |p 45 
998 |g 1237589290  |a Hanebeck, Jennifer  |m 1237589290:Hanebeck, Jennifer  |d 910000  |d 910500  |e 910000PH1237589290  |e 910500PH1237589290  |k 0/910000/  |k 1/910000/910500/  |p 33 
998 |g 1078266212  |a Haber, Benjamin  |m 1078266212:Haber, Benjamin  |d 910000  |d 910500  |e 910000PH1078266212  |e 910500PH1078266212  |k 0/910000/  |k 1/910000/910500/  |p 30 
999 |a KXP-PPN1764273338  |e 3957443687 
BIB |a Y 
SER |a journal 
JSO |a {"relHost":[{"language":["eng"],"name":{"displayForm":["American Society of Human Genetics"]},"part":{"extent":"11","volume":"108","year":"2021","pages":"346-356","text":"108(2021), 2 vom: Feb., Seite 346-356","issue":"2"},"pubHistory":["1.1949 -"],"title":[{"title":"The American journal of human genetics","title_sort":"American journal of human genetics"}],"origin":[{"publisherPlace":"New York, NY [u.a.] ; New York, NY ; Chicago, Ill.","dateIssuedKey":"1949","dateIssuedDisp":"1949-","publisher":"Cell Press ; Elsevier ; Univ. of Chicago Press"}],"corporate":[{"display":"American Society of Human Genetics","role":"isb","roleDisplay":"Herausgebendes Organ"}],"recId":"269019014","note":["Gesehen am 28.05.2020"],"id":{"issn":["1537-6605"],"zdb":["1473813-2"],"eki":["269019014"]},"disp":"Mutation-specific pathophysiological mechanisms define different neurodevelopmental disorders associated with SATB1 dysfunctionThe American journal of human genetics","type":{"bibl":"periodical","media":"Online-Ressource"}}],"name":{"displayForm":["Joery den Hoed, Elke de Boer, Norine Voisin, Alexander J.M. Dingemans, Nicolas Guex, Laurens Wiel, Christoffer Nellaker, Shivarajan M. Amudhavalli, Siddharth Banka, Frederique S. Bena, Bruria Ben-Zeev, Vincent R. Bonagura, Ange-Line Bruel, Theresa Brunet, Han G. Brunner, Hui B. Chew, Jacqueline Chrast, Loreta Cimbalistienė, Hilary Coon, Emmanuèlle C. Délot, Florence Démurger, Anne-Sophie Denommé-Pichon, Christel Depienne, Dian Donnai, David A. Dyment, Orly Elpeleg, Laurence Faivre, Christian Gilissen, Leslie Granger, Benjamin Haber, Yasuo Hachiya, Yasmin Hamzavi Abedi, Jennifer Hanebeck, Jayne Y. Hehir-Kwa, Brooke Horist, Toshiyuki Itai, Adam Jackson, Rosalyn Jewell, Kelly L. Jones, Shelagh Joss, Hirofumi Kashii, Mitsuhiro Kato, Anja A. Kattentidt-Mouravieva, Fernando Kok, Urania Kotzaeridou, Vidya Krishnamurthy, Vaidutis Kučinskas, Alma Kuechler, Alinoë Lavillaureix, Pengfei Liu, Linda Manwaring, Naomichi Matsumoto, Benoît Mazel, Kirsty McWalter, Vardiella Meiner, Mohamad A. Mikati, Satoko Miyatake, Takeshi Mizuguchi, Lip H. Moey, Shehla Mohammed, Hagar Mor-Shaked, Hayley Mountford, Ruth Newbury-Ecob, Sylvie Odent, Laura Orec, Matthew Osmond, Timothy B. Palculict, Michael Parker, Andrea K. Petersen, Rolph Pfundt, Eglė Preikšaitienė, Kelly Radtke, Emmanuelle Ranza, Jill A. Rosenfeld, Teresa Santiago-Sim, Caitlin Schwager, Margje Sinnema, Lot Snijders Blok, Rebecca C. Spillmann, Alexander P.A. Stegmann, Isabelle Thiffault, Linh Tran, Adi Vaknin-Dembinsky, Juliana H. Vedovato-dos-Santos, Samantha A. Schrier Vergano, Eric Vilain, Antonio Vitobello, Matias Wagner, Androu Waheeb, Marcia Willing, Britton Zuccarelli, Usha Kini, Dianne F. Newbury, Tjitske Kleefstra, Alexandre Reymond, Simon E. Fisher, Lisenka E.L.M. Vissers"]},"language":["eng"],"recId":"1764273338","note":["Gesehen am 24.07.2021"],"id":{"eki":["1764273338"],"doi":["10.1016/j.ajhg.2021.01.007"]},"person":[{"given":"Joery den","roleDisplay":"VerfasserIn","role":"aut","family":"Hoed","display":"Hoed, Joery den"},{"role":"aut","roleDisplay":"VerfasserIn","given":"Elke","family":"de Boer","display":"de Boer, Elke"},{"given":"Norine","roleDisplay":"VerfasserIn","role":"aut","display":"Voisin, Norine","family":"Voisin"},{"role":"aut","given":"Alexander J. M.","roleDisplay":"VerfasserIn","display":"Dingemans, Alexander J. M.","family":"Dingemans"},{"display":"Guex, Nicolas","family":"Guex","roleDisplay":"VerfasserIn","given":"Nicolas","role":"aut"},{"family":"Wiel","display":"Wiel, Laurens","roleDisplay":"VerfasserIn","given":"Laurens","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","given":"Christoffer","family":"Nellaker","display":"Nellaker, Christoffer"},{"display":"Amudhavalli, Shivarajan M.","family":"Amudhavalli","roleDisplay":"VerfasserIn","given":"Shivarajan M.","role":"aut"},{"family":"Banka","display":"Banka, Siddharth","role":"aut","roleDisplay":"VerfasserIn","given":"Siddharth"},{"family":"Bena","display":"Bena, Frederique S.","role":"aut","roleDisplay":"VerfasserIn","given":"Frederique S."},{"family":"Ben-Zeev","display":"Ben-Zeev, Bruria","role":"aut","given":"Bruria","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","given":"Vincent R.","role":"aut","display":"Bonagura, Vincent R.","family":"Bonagura"},{"display":"Bruel, Ange-Line","family":"Bruel","role":"aut","given":"Ange-Line","roleDisplay":"VerfasserIn"},{"role":"aut","given":"Theresa","roleDisplay":"VerfasserIn","family":"Brunet","display":"Brunet, Theresa"},{"role":"aut","given":"Han G.","roleDisplay":"VerfasserIn","display":"Brunner, Han G.","family":"Brunner"},{"display":"Chew, Hui B.","family":"Chew","given":"Hui B.","roleDisplay":"VerfasserIn","role":"aut"},{"display":"Chrast, Jacqueline","family":"Chrast","given":"Jacqueline","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","given":"Loreta","family":"Cimbalistienė","display":"Cimbalistienė, Loreta"},{"role":"aut","roleDisplay":"VerfasserIn","given":"Hilary","family":"Coon","display":"Coon, Hilary"},{"family":"Délot","display":"Délot, Emmanuèlle C.","given":"Emmanuèlle C.","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Florence","roleDisplay":"VerfasserIn","role":"aut","display":"Démurger, Florence","family":"Démurger"},{"family":"Denommé-Pichon","display":"Denommé-Pichon, Anne-Sophie","role":"aut","roleDisplay":"VerfasserIn","given":"Anne-Sophie"},{"display":"Depienne, Christel","family":"Depienne","roleDisplay":"VerfasserIn","given":"Christel","role":"aut"},{"role":"aut","given":"Dian","roleDisplay":"VerfasserIn","family":"Donnai","display":"Donnai, Dian"},{"role":"aut","roleDisplay":"VerfasserIn","given":"David A.","family":"Dyment","display":"Dyment, David A."},{"given":"Orly","roleDisplay":"VerfasserIn","role":"aut","display":"Elpeleg, Orly","family":"Elpeleg"},{"role":"aut","roleDisplay":"VerfasserIn","given":"Laurence","family":"Faivre","display":"Faivre, Laurence"},{"display":"Gilissen, Christian","family":"Gilissen","roleDisplay":"VerfasserIn","given":"Christian","role":"aut"},{"roleDisplay":"VerfasserIn","given":"Leslie","role":"aut","display":"Granger, Leslie","family":"Granger"},{"role":"aut","roleDisplay":"VerfasserIn","given":"Benjamin","family":"Haber","display":"Haber, Benjamin"},{"given":"Yasuo","roleDisplay":"VerfasserIn","role":"aut","family":"Hachiya","display":"Hachiya, Yasuo"},{"roleDisplay":"VerfasserIn","given":"Yasmin Hamzavi","role":"aut","family":"Abedi","display":"Abedi, Yasmin Hamzavi"},{"roleDisplay":"VerfasserIn","given":"Jennifer","role":"aut","family":"Hanebeck","display":"Hanebeck, Jennifer"},{"display":"Hehir-Kwa, Jayne Y.","family":"Hehir-Kwa","roleDisplay":"VerfasserIn","given":"Jayne Y.","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","given":"Brooke","display":"Horist, Brooke","family":"Horist"},{"role":"aut","given":"Toshiyuki","roleDisplay":"VerfasserIn","display":"Itai, Toshiyuki","family":"Itai"},{"display":"Kotzaeridou, Urania","family":"Kotzaeridou","role":"aut","roleDisplay":"VerfasserIn","given":"Urania"},{"display":"Orec, Laura","family":"Orec","given":"Laura","roleDisplay":"VerfasserIn","role":"aut"}],"title":[{"title":"Mutation-specific pathophysiological mechanisms define different neurodevelopmental disorders associated with SATB1 dysfunction","title_sort":"Mutation-specific pathophysiological mechanisms define different neurodevelopmental disorders associated with SATB1 dysfunction"}],"physDesc":[{"extent":"11 S."}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"origin":[{"dateIssuedDisp":"28 January 2021","dateIssuedKey":"2021"}]} 
SRT |a HOEDJOERYDMUTATIONSP2820 

Similar Items