Effect of increased lactate dehydrogenase A activity and aerobic glycolysis on the proinflammatory profile of autoimmune CD8+ T cells in rheumatoid arthritis

Objective - CD8+ T cells contribute to rheumatoid arthritis (RA) by releasing proinflammatory and cytolytic mediators, even in a challenging hypoxic and nutrient-poor microenvironment such as the synovial membrane.

Bibliographic Details

Main Authors:	Souto-Carneiro, Maria Margarida (Author) , Klika, Karel D. (Author) , Abreu, Mónica T. (Author) , Meyer, André P. (Author) , Saffrich, Rainer (Author) , Sandhoff, Roger (Author) , Jennemann, Richard (Author) , Kraus, Franziska V. (Author) , Tykocinski, Lars-Oliver (Author) , Eckstein, Volker (Author) , Carvalho, Lina (Author) , Kriegsmann, Mark (Author) , Giese, Thomas (Author) , Lorenz, Hanns-Martin (Author) , Carvalho, Rui A. (Author)
Format:	Article (Journal)
Language:	English
Published:	2020
In:	Arthritis & rheumatology Year: 2020, Volume: 72, Issue: 12, Pages: 2050-2064
ISSN:	2326-5205
DOI:	10.1002/art.41420
Online Access:	Verlag, kostenfrei, Volltext: https://doi.org/10.1002/art.41420 Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/10.1002/art.41420
Author Notes:	M. Margarida Souto-Carneiro, Karel D. Klika, Mónica T. Abreu, André P. Meyer, Rainer Saffrich, Roger Sandhoff, Richard Jennemann, Franziska V. Kraus, Lars Tykocinski, Volker Eckstein, Lina Carvalho, Mark Kriegsmann, Thomas Giese, Hanns-Martin Lorenz, and Rui A. Carvalho