Effect of increased lactate dehydrogenase A activity and aerobic glycolysis on the proinflammatory profile of autoimmune CD8+ T cells in rheumatoid arthritis
Objective - CD8+ T cells contribute to rheumatoid arthritis (RA) by releasing proinflammatory and cytolytic mediators, even in a challenging hypoxic and nutrient-poor microenvironment such as the synovial membrane.
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| Hauptverfasser: | , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2020
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| In: |
Arthritis & rheumatology
Year: 2020, Jahrgang: 72, Heft: 12, Pages: 2050-2064 |
| ISSN: | 2326-5205 |
| DOI: | 10.1002/art.41420 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1002/art.41420 Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/10.1002/art.41420 |
| Verfasserangaben: | M. Margarida Souto-Carneiro, Karel D. Klika, Mónica T. Abreu, André P. Meyer, Rainer Saffrich, Roger Sandhoff, Richard Jennemann, Franziska V. Kraus, Lars Tykocinski, Volker Eckstein, Lina Carvalho, Mark Kriegsmann, Thomas Giese, Hanns-Martin Lorenz, and Rui A. Carvalho |
| Zusammenfassung: | Objective - CD8+ T cells contribute to rheumatoid arthritis (RA) by releasing proinflammatory and cytolytic mediators, even in a challenging hypoxic and nutrient-poor microenvironment such as the synovial membrane. |
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| Beschreibung: | First published: 30 June 2020 Gesehen am 20.12.2021 |
| Beschreibung: | Online Resource |
| ISSN: | 2326-5205 |
| DOI: | 10.1002/art.41420 |