Cover Image

Sepsis of patients infected by SARS-CoV-2: real-world experience from the international HOPE-COVID-19-Registry and Validation of HOPE Sepsis Score

Background: Patients with sepsis with a concomitant coronavirus (COVID-19) infection are related to a high morbidity and mortality rate. We investigated a large cohort of patients with sepsis with a concomitant COVID-19, and we developed a risk score for the estimation of sepsis risk in COVID-19.Met...

Full description

Saved in:
Bibliographic Details
Main Authors: Abumayyaleh, Mohammad S. A. (Author) , Nuñez-Gil, Iván J. (Author) , El-Battrawy, Ibrahim (Author) , Estrada, Vicente (Author) , Becerra-Muñoz, Víctor Manuel (Author) , Uribarri, Aitor (Author) , Fernández-Rozas, Inmaculada (Author) , Feltes, Gisela (Author) , Arroyo-Espliguero, Ramón (Author) , Trabattoni, Daniela (Author) , López Pais, Javier (Author) , Pepe, Martino (Author) , Romero, Rodolfo (Author) , Ortega-Armas, María Elizabeth (Author) , Bianco, Matteo (Author) , Astrua, Thamar Capel (Author) , D'Ascenzo, Fabrizio (Author) , Fabregat-Andres, Oscar (Author) , Ballester, Andrea (Author) , Marín, Francisco (Author) , Buonsenso, Danilo (Author) , Sanchez-Gimenez, Raul (Author) , Weiß, Christel (Author) , Fernandez Perez, Cristina (Author) , Fernández-Ortiz, Antonio (Author) , Macaya, Carlos (Author) , Akın, Ibrahim (Author)
Format: Article (Journal)
Language:English
Published: 14 October 2021
In: Frontiers in medicine
Year: 2021, Volume: 8, Pages: 1-10
ISSN:2296-858X
DOI:10.3389/fmed.2021.728102
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3389/fmed.2021.728102
Verlag, kostenfrei, Volltext: https://www.frontiersin.org/article/10.3389/fmed.2021.728102
Get full text
Author Notes:Mohammad Abumayyaleh, Iván J. Nuñez-Gil, Ibrahim El-Battrawy, Vicente Estrada, Víctor Manuel Becerra-Muñoz, Aitor Uribarri, Inmaculada Fernández-Rozas, Gisela Feltes, Ramón Arroyo-Espliguero, Daniela Trabattoni, Javier López Pais, Martino Pepe, Rodolfo Romero, María Elizabeth Ortega-Armas, Matteo Bianco, Thamar Capel Astrua, Fabrizio D'Ascenzo, Oscar Fabregat-Andres, Andrea Ballester, Francisco Marín, Danilo Buonsenso, Raul Sanchez-Gimenez, Christel Weiß, Cristina Fernandez Perez, Antonio Fernández-Ortiz, Carlos Macaya, Ibrahim Akin and HOPE COVID-19 investigators
Description
Summary:Background: Patients with sepsis with a concomitant coronavirus (COVID-19) infection are related to a high morbidity and mortality rate. We investigated a large cohort of patients with sepsis with a concomitant COVID-19, and we developed a risk score for the estimation of sepsis risk in COVID-19.Methods: We conducted a sub-analysis from the international Health Outcome Predictive Evaluation Registry for COVID-19 (HOPE-COVID-19-Registry, NCT04334291). Out of 5,837 patients with COVID-19, 624 patients were diagnosed with sepsis according to the Sepsis-3 International Consensus.Results: In multivariable analysis, the following risk factors were identified as independent predictors for developing sepsis: current smoking, tachypnoea (>22 breath per minute), hemoptysis, peripheral oxygen saturation (SpO2) <92%, blood pressure (BP) (systolic BP <90 mmHg and diastolic BP <60 mmHg), Glasgow Coma Scale (GCS) <15, elevated procalcitonin (PCT), elevated troponin I (TnI), and elevated creatinine >1.5 mg/dl. By assigning odds ratio (OR) weighted points to these variables, the following three risk categories were defined to develop sepsis during admission: low-risk group (probability of sepsis 3.1-11.8%); intermediate-risk group (24.8-53.8%); and high-risk-group (58.3-100%). A score of 1 was assigned to current smoking, tachypnoea, decreased SpO2, decreased BP, decreased GCS, elevated PCT, TnI, and creatinine, whereas a score of 2 was assigned to hemoptysis.Conclusions: The HOPE Sepsis Score including nine parameters is useful in identifying high-risk COVID-19 patients to develop sepsis. Sepsis in COVID-19 is associated with a high mortality rate.
Item Description:Gesehen am 23.12.2021
Physical Description:Online Resource
ISSN:2296-858X
DOI:10.3389/fmed.2021.728102

Similar Items