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Sepsis of patients infected by SARS-CoV-2: real-world experience from the international HOPE-COVID-19-Registry and Validation of HOPE Sepsis Score

Background: Patients with sepsis with a concomitant coronavirus (COVID-19) infection are related to a high morbidity and mortality rate. We investigated a large cohort of patients with sepsis with a concomitant COVID-19, and we developed a risk score for the estimation of sepsis risk in COVID-19.Met...

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Hauptverfasser: Abumayyaleh, Mohammad S. A. (VerfasserIn) , Nuñez-Gil, Iván J. (VerfasserIn) , El-Battrawy, Ibrahim (VerfasserIn) , Estrada, Vicente (VerfasserIn) , Becerra-Muñoz, Víctor Manuel (VerfasserIn) , Uribarri, Aitor (VerfasserIn) , Fernández-Rozas, Inmaculada (VerfasserIn) , Feltes, Gisela (VerfasserIn) , Arroyo-Espliguero, Ramón (VerfasserIn) , Trabattoni, Daniela (VerfasserIn) , López Pais, Javier (VerfasserIn) , Pepe, Martino (VerfasserIn) , Romero, Rodolfo (VerfasserIn) , Ortega-Armas, María Elizabeth (VerfasserIn) , Bianco, Matteo (VerfasserIn) , Astrua, Thamar Capel (VerfasserIn) , D'Ascenzo, Fabrizio (VerfasserIn) , Fabregat-Andres, Oscar (VerfasserIn) , Ballester, Andrea (VerfasserIn) , Marín, Francisco (VerfasserIn) , Buonsenso, Danilo (VerfasserIn) , Sanchez-Gimenez, Raul (VerfasserIn) , Weiß, Christel (VerfasserIn) , Fernandez Perez, Cristina (VerfasserIn) , Fernández-Ortiz, Antonio (VerfasserIn) , Macaya, Carlos (VerfasserIn) , Akın, Ibrahim (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 14 October 2021
In: Frontiers in medicine
Year: 2021, Jahrgang: 8, Pages: 1-10
ISSN:2296-858X
DOI:10.3389/fmed.2021.728102
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.3389/fmed.2021.728102
Verlag, kostenfrei, Volltext: https://www.frontiersin.org/article/10.3389/fmed.2021.728102
Volltext
Verfasserangaben:Mohammad Abumayyaleh, Iván J. Nuñez-Gil, Ibrahim El-Battrawy, Vicente Estrada, Víctor Manuel Becerra-Muñoz, Aitor Uribarri, Inmaculada Fernández-Rozas, Gisela Feltes, Ramón Arroyo-Espliguero, Daniela Trabattoni, Javier López Pais, Martino Pepe, Rodolfo Romero, María Elizabeth Ortega-Armas, Matteo Bianco, Thamar Capel Astrua, Fabrizio D'Ascenzo, Oscar Fabregat-Andres, Andrea Ballester, Francisco Marín, Danilo Buonsenso, Raul Sanchez-Gimenez, Christel Weiß, Cristina Fernandez Perez, Antonio Fernández-Ortiz, Carlos Macaya, Ibrahim Akin and HOPE COVID-19 investigators
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Zusammenfassung:Background: Patients with sepsis with a concomitant coronavirus (COVID-19) infection are related to a high morbidity and mortality rate. We investigated a large cohort of patients with sepsis with a concomitant COVID-19, and we developed a risk score for the estimation of sepsis risk in COVID-19.Methods: We conducted a sub-analysis from the international Health Outcome Predictive Evaluation Registry for COVID-19 (HOPE-COVID-19-Registry, NCT04334291). Out of 5,837 patients with COVID-19, 624 patients were diagnosed with sepsis according to the Sepsis-3 International Consensus.Results: In multivariable analysis, the following risk factors were identified as independent predictors for developing sepsis: current smoking, tachypnoea (>22 breath per minute), hemoptysis, peripheral oxygen saturation (SpO2) <92%, blood pressure (BP) (systolic BP <90 mmHg and diastolic BP <60 mmHg), Glasgow Coma Scale (GCS) <15, elevated procalcitonin (PCT), elevated troponin I (TnI), and elevated creatinine >1.5 mg/dl. By assigning odds ratio (OR) weighted points to these variables, the following three risk categories were defined to develop sepsis during admission: low-risk group (probability of sepsis 3.1-11.8%); intermediate-risk group (24.8-53.8%); and high-risk-group (58.3-100%). A score of 1 was assigned to current smoking, tachypnoea, decreased SpO2, decreased BP, decreased GCS, elevated PCT, TnI, and creatinine, whereas a score of 2 was assigned to hemoptysis.Conclusions: The HOPE Sepsis Score including nine parameters is useful in identifying high-risk COVID-19 patients to develop sepsis. Sepsis in COVID-19 is associated with a high mortality rate.
Beschreibung:Gesehen am 23.12.2021
Beschreibung:Online Resource
ISSN:2296-858X
DOI:10.3389/fmed.2021.728102

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