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Mutations in TP53 or DNA damage repair genes define poor prognostic subgroups in primary prostate cancer

Background - Mutations in DNA damage repair genes, in particular genes involved in homology-directed repair, define a subgroup of men with prostate cancer with a more unfavorable prognosis but a therapeutic vulnerability to PARP inhibition. In current practice, mutational testing of prostate cancer...

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Main Authors: Nientiedt, Cathleen (Author) , Budczies, Jan (Author) , Endris, Volker (Author) , Kirchner, Martina (Author) , Schwab, Constantin (Author) , Jurcic, Christina (Author) , Behnisch, Rouven (Author) , Hoveida, Shirin (Author) , Lantwin, Philippa (Author) , Kaczorowski, Adam (Author) , Geisler, Christine (Author) , Dieffenbacher, Svenja (Author) , Falkenbach, Fabian (Author) , Franke, Désirée (Author) , Görtz, Magdalena (Author) , Heller, Martina (Author) , Himmelsbach, Ruth (Author) , Pecqueux, Carine (Author) , Rath, Mathias (Author) , Reimold, Philipp (Author) , Schütz, Viktoria (Author) , Simunovic, Iva (Author) , Walter, Elena (Author) , Hofer, Luisa (Author) , Gasch, Claudia (Author) , Schoenberg, Gita (Author) , Pursche, Lars (Author) , Hatiboglu, Gencay (Author) , Nyarangi-Dix, Joanne (Author) , Sültmann, Holger (Author) , Zschäbitz, Stefanie (Author) , Körber, Stefan A. (Author) , Jäger, Dirk (Author) , Debus, Jürgen (Author) , Duensing, Anette (Author) , Schirmacher, Peter (Author) , Hohenfellner, Markus (Author) , Stenzinger, Albrecht (Author) , Duensing, Stefan (Author)
Format: Article (Journal)
Language:English
Published: January 2022
In: Urologic oncology
Year: 2022, Volume: 40, Issue: 1, Pages: 8.e11-8.e18
ISSN:1873-2496
DOI:10.1016/j.urolonc.2021.06.024
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.urolonc.2021.06.024
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S107814392100301X
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Author Notes:Cathleen Nientiedt, Jan Budczies, Volker Endris, Martina Kirchner, Constantin Schwab, Christina Jurcic, Rouven Behnisch, Shirin Hoveida, Philippa Lantwin, Adam Kaczorowski, Christine Geisler, Svenja Dieffenbacher, Fabian Falkenbach, Desiree Franke, Magdalena Görtz, Martina Heller, Ruth Himmelsbach, Carine Pecqueux, Mathias Rath, Philipp Reimold, Viktoria Schütz, Iva Simunovic, Elena Walter, Luisa Hofer, Claudia Gasch, Gita Schönberg, Lars Pursche, Gencay Hatiboglu, Joanne Nyarangi-Dix, Holger Sültmann, Stefanie Zschäbitz, Stefan A. Koerber, Dirk Jäger, Jürgen Debus, Anette Duensing, Peter Schirmacher, Markus Hohenfellner, Albrecht Stenzinger, Stefan Duensing
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Summary:Background - Mutations in DNA damage repair genes, in particular genes involved in homology-directed repair, define a subgroup of men with prostate cancer with a more unfavorable prognosis but a therapeutic vulnerability to PARP inhibition. In current practice, mutational testing of prostate cancer patients is commonly done late i.e., when the tumor is castration resistant. In addition, most sequencing panels do not include TP53, one of the most crucial tumor suppressor genes in human cancer. In this proof-of-concept study, we sought to extend the clinical use of these molecular markers by exploring the early prognostic impact of mutations in TP53 and DNA damage repair genes in men with primary, nonmetastatic prostate cancer undergoing radical prostatectomy (RPX).
Item Description:Online verfügbar 26. Juli 2021, Version des Artikels 1. Dezember 2021
Gesehen am 17.01.2022
Physical Description:Online Resource
ISSN:1873-2496
DOI:10.1016/j.urolonc.2021.06.024

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