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High SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinoma

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Several lines of evidence indicate that Sirt1, a class III histone deacetylase (HDAC) is implicated in the initiation and progression of malignancies and thus gained attraction as druggable target. Since data on the role of Sirt1 in pancreatic ductal adenocarcinoma (PDAC) are sparse, we investigated...

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Main Authors: Stenzinger, Albrecht (Author) , Endris, Volker (Author) , Klauschen, Frederick (Author) , Sinn, Bruno (Author) , Lorenz, Katja (Author) , Warth, Arne (Author) , Goeppert, Benjamin (Author) , Ehemann, Volker (Author) , Muckenhuber, Alexander (Author) , Kamphues, Carsten (Author) , Bahra, Marcus (Author) , Neuhaus, Peter (Author) , Weichert, Wilko (Author)
Format: Article (Journal)
Language:English
Published: 2013
In: BMC cancer
Year: 2013, Volume: 13, Pages: 1-12
ISSN:1471-2407
DOI:10.1186/1471-2407-13-450
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/1471-2407-13-450
Verlag, kostenfrei, Volltext: https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-13-450
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Author Notes:Albrecht Stenzinger, Volker Endris, Frederick Klauschen, Bruno Sinn, Katja Lorenz, Arne Warth, Benjamin Goeppert, Volker Ehemann, Alexander Muckenhuber, Carsten Kamphues, Marcus Bahra, Peter Neuhaus and Wilko Weichert
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Summary:Several lines of evidence indicate that Sirt1, a class III histone deacetylase (HDAC) is implicated in the initiation and progression of malignancies and thus gained attraction as druggable target. Since data on the role of Sirt1 in pancreatic ductal adenocarcinoma (PDAC) are sparse, we investigated the expression profile and prognostic significance of Sirt1 in vivo as well as cellular effects of Sirt1 inhibition in vitro.
Item Description:Gesehen am 21.02.2022
Physical Description:Online Resource
ISSN:1471-2407
DOI:10.1186/1471-2407-13-450

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