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Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B

Long-term complications such as radiation-induced second malignancies occur in a subset of patients following radiation-therapy, particularly relevant in pediatric patients due to the long follow-up period in case of survival. Radiation-induced gliomas (RIGs) have been reported in patients after tre...

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Main Authors: Deng, Maximilian (Author) , Sturm, Dominik (Author) , Pfaff, Elke (Author) , Sill, Martin (Author) , Stichel, Damian (Author) , Balasubramanian, Gnana Prakash (Author) , Tippelt, Stephan (Author) , Kramm, Christof (Author) , Donson, Andrew M. (Author) , Green, Adam L. (Author) , Jones, Chris (Author) , Schittenhelm, Jens (Author) , Ebinger, Martin (Author) , Schuhmann, Martin U. (Author) , Jones, Barbara Christine (Author) , Tilburg, Cornelis M. van (Author) , Wittmann, Andrea (Author) , Golanov, Andrey (Author) , Ryzhova, Marina (Author) , Ecker, Jonas (Author) , Milde, Till (Author) , Witt, Olaf (Author) , Sahm, Felix (Author) , Reuss, David (Author) , Sumerauer, David (Author) , Zamecnik, Josef (Author) , Korshunov, Andrey (Author) , Deimling, Andreas von (Author) , Pfister, Stefan (Author) , Jones, David T. W. (Author)
Format: Article (Journal)
Language:English
Published: 20 September 2021
In: Nature Communications
Year: 2021, Volume: 12, Pages: 1-11
ISSN:2041-1723
DOI:10.1038/s41467-021-25708-y
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41467-021-25708-y
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41467-021-25708-y
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Author Notes:Maximilian Y. Deng, Dominik Sturm, Elke Pfaff, Martin Sill, Damian Stichel, Gnana Prakash Balasubramanian, Stephan Tippelt, Christof Kramm, Andrew M. Donson, Adam L. Green, Chris Jones, Jens Schittenhelm, Martin Ebinger, Martin U. Schuhmann, Barbara C. Jones, Cornelis M. van Tilburg, Andrea Wittmann, Andrey Golanov, Marina Ryzhova, Jonas Ecker, Till Milde, Olaf Witt, Felix Sahm, David Reuss, David Sumerauer, Josef Zamecnik, Andrey Korshunov, Andreas von Deimling, Stefan M. Pfister, David T.W. Jones
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Summary:Long-term complications such as radiation-induced second malignancies occur in a subset of patients following radiation-therapy, particularly relevant in pediatric patients due to the long follow-up period in case of survival. Radiation-induced gliomas (RIGs) have been reported in patients after treatment with cranial irradiation for various primary malignancies such as acute lymphoblastic leukemia (ALL) and medulloblastoma (MB). We perform comprehensive (epi-) genetic and expression profiling of RIGs arising after cranial irradiation for MB (n = 23) and ALL (n = 9). Our study reveals a unifying molecular signature for the majority of RIGs, with recurrent PDGFRA amplification and loss of CDKN2A/B and an absence of somatic hotspot mutations in genes encoding histone 3 variants or IDH1/2, uncovering diagnostic markers and potentially actionable targets.
Item Description:Published 20 September 2021
Gesehen am 23.03.2022
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-021-25708-y

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