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The cyclin E regulator cullin 3 prevents mouse hepatic progenitor cells from becoming tumor-initiating cells

Cyclin E is often overexpressed in cancer tissue, leading to genetic instability and aneuploidy. Cullin 3 (Cul3) is a component of the BTB-Cul3-Rbx1 (BCR) ubiquitin ligase that is involved in the turnover of cyclin E. Here we show that liver-specific ablation of Cul3 in mice results in the persisten...

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Main Authors: Kossatz-Böhlert, Uta (Author) , Breuhahn, Kai (Author) , Wolf, Benita (Author) , Hardtke-Wolenski, Matthias (Author) , Wilkens, Ludwig (Author) , Steinemann, Doris (Author) , Singer, Stephan (Author) , Brass, Felicitas (Author) , Kubicka, Stefan (Author) , Schlegelberger, Brigitte (Author) , Schirmacher, Peter (Author) , Manns, Michael P. (Author) , Singer, Jeffrey D. (Author) , Malek, Nisar P. (Author)
Format: Article (Journal)
Language:English
Published: October 11, 2010
In: The journal of clinical investigation
Year: 2010, Volume: 120, Issue: 11, Pages: 3820-3833
ISSN:1558-8238
DOI:10.1172/JCI41959
Online Access:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1172/JCI41959
Verlag, kostenfrei, Volltext: https://www.jci.org/articles/view/41959
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Author Notes:Uta Kossatz, Kai Breuhahn, Benita Wolf, Matthias Hardtke-Wolenski, Ludwig Wilkens, Doris Steinemann, Stephan Singer, Felicitas Brass, Stefan Kubicka, Brigitte Schlegelberger, Peter Schirmacher, Michael P. Manns, Jeffrey D. Singer, and Nisar P. Malek
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Summary:Cyclin E is often overexpressed in cancer tissue, leading to genetic instability and aneuploidy. Cullin 3 (Cul3) is a component of the BTB-Cul3-Rbx1 (BCR) ubiquitin ligase that is involved in the turnover of cyclin E. Here we show that liver-specific ablation of Cul3 in mice results in the persistence and massive expansion of hepatic progenitor cells.
Item Description:Gesehen am 22.03.2023
Physical Description:Online Resource
ISSN:1558-8238
DOI:10.1172/JCI41959

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