Buchumschlag

The cyclin E regulator cullin 3 prevents mouse hepatic progenitor cells from becoming tumor-initiating cells

Cyclin E is often overexpressed in cancer tissue, leading to genetic instability and aneuploidy. Cullin 3 (Cul3) is a component of the BTB-Cul3-Rbx1 (BCR) ubiquitin ligase that is involved in the turnover of cyclin E. Here we show that liver-specific ablation of Cul3 in mice results in the persisten...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Kossatz-Böhlert, Uta (VerfasserIn) , Breuhahn, Kai (VerfasserIn) , Wolf, Benita (VerfasserIn) , Hardtke-Wolenski, Matthias (VerfasserIn) , Wilkens, Ludwig (VerfasserIn) , Steinemann, Doris (VerfasserIn) , Singer, Stephan (VerfasserIn) , Brass, Felicitas (VerfasserIn) , Kubicka, Stefan (VerfasserIn) , Schlegelberger, Brigitte (VerfasserIn) , Schirmacher, Peter (VerfasserIn) , Manns, Michael P. (VerfasserIn) , Singer, Jeffrey D. (VerfasserIn) , Malek, Nisar P. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: October 11, 2010
In: The journal of clinical investigation
Year: 2010, Jahrgang: 120, Heft: 11, Pages: 3820-3833
ISSN:1558-8238
DOI:10.1172/JCI41959
Online-Zugang:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1172/JCI41959
Verlag, kostenfrei, Volltext: https://www.jci.org/articles/view/41959
Volltext
Verfasserangaben:Uta Kossatz, Kai Breuhahn, Benita Wolf, Matthias Hardtke-Wolenski, Ludwig Wilkens, Doris Steinemann, Stephan Singer, Felicitas Brass, Stefan Kubicka, Brigitte Schlegelberger, Peter Schirmacher, Michael P. Manns, Jeffrey D. Singer, and Nisar P. Malek
Beschreibung
Zusammenfassung:Cyclin E is often overexpressed in cancer tissue, leading to genetic instability and aneuploidy. Cullin 3 (Cul3) is a component of the BTB-Cul3-Rbx1 (BCR) ubiquitin ligase that is involved in the turnover of cyclin E. Here we show that liver-specific ablation of Cul3 in mice results in the persistence and massive expansion of hepatic progenitor cells.
Beschreibung:Gesehen am 22.03.2023
Beschreibung:Online Resource
ISSN:1558-8238
DOI:10.1172/JCI41959

Ähnliche Einträge