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Live-virus neutralization of the omicron variant in children and adults 14 months after SARS-CoV-2 wild-type infection

Data on cross-neutralization of the SARS-CoV-2 omicron variant more than 1 year after SARS-CoV-2 infection are urgently needed, especially in children, to predict the likelihood of reinfection and to guide vaccination strategies. In a prospective observational cohort study, we evaluated live-virus n...

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Hauptverfasser: Stich, Maximilian (VerfasserIn) , Benning, Louise (VerfasserIn) , Speer, Claudius (VerfasserIn) , Garbade, Sven (VerfasserIn) , Bartenschlager, Marie (VerfasserIn) , Kim, Heeyoung (VerfasserIn) , Jeltsch, Kathrin (VerfasserIn) , Tabatabai, Julia (VerfasserIn) , Niesert, Moritz (VerfasserIn) , Janda, Aleš (VerfasserIn) , Renk, Hanna (VerfasserIn) , Elling, Roland (VerfasserIn) , Hoffmann, Georg F. (VerfasserIn) , Kräusslich, Hans-Georg (VerfasserIn) , Müller, Barbara (VerfasserIn) , Bartenschlager, Ralf (VerfasserIn) , Tönshoff, Burkhard (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 16 February 2023
In: Journal of medical virology
Year: 2023, Jahrgang: 95, Heft: 3, Pages: 1-11
ISSN:1096-9071
DOI:10.1002/jmv.28582
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1002/jmv.28582
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.28582
Volltext
Verfasserangaben:Maximilian Stich, Louise Benning, Claudius Speer, Sven F. Garbade, Marie Bartenschlager, Heeyoung Kim, Kathrin Jeltsch, Julia Tabatabai, Moritz Niesert, Aleš Janda, Hanna Renk, Roland Elling, Georg Friedrich Hoffmann, Hans-Georg Kräusslich, Barbara Müller, Ralf Bartenschlager, Burkhard Tönshoff
Beschreibung
Zusammenfassung:Data on cross-neutralization of the SARS-CoV-2 omicron variant more than 1 year after SARS-CoV-2 infection are urgently needed, especially in children, to predict the likelihood of reinfection and to guide vaccination strategies. In a prospective observational cohort study, we evaluated live-virus neutralization of the SARS-CoV-2 omicron (BA.1) variant in children compared with adults 14 months after mild or asymptomatic wild-type SARS-CoV-2 infection. We also evaluated immunity to reinfection conferred by previous infection plus COVID-19 mRNA vaccination. We studied 36 adults and 34 children 14 months after acute SARS-CoV-2 infection. While 94% of unvaccinated adults (16/17) and children (32/34) neutralized the delta (B.1.617.2) variant, only 1/17 (5.9%) unvaccinated adults, 0/16 (0%) adolescents and 5/18 (27.8%) children <12 years of age had neutralizing activity against omicron (BA.1). In convalescent adults, one or two doses of mRNA vaccine increased delta and omicron neutralization 32-fold, similar to a third mRNA vaccination in uninfected adults. Neutralization of omicron was 8-fold lower than that of delta in both groups. In conclusion, our data indicate that humoral immunity induced by previous SARS-CoV-2 wild-type infection more than 1 year ago is insufficient to neutralize the current immune escape omicron variant.
Beschreibung:Gesehen am 22.05.2023
Beschreibung:Online Resource
ISSN:1096-9071
DOI:10.1002/jmv.28582

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