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Live-virus neutralization of the omicron variant in children and adults 14 months after SARS-CoV-2 wild-type infection

Data on cross-neutralization of the SARS-CoV-2 omicron variant more than 1 year after SARS-CoV-2 infection are urgently needed, especially in children, to predict the likelihood of reinfection and to guide vaccination strategies. In a prospective observational cohort study, we evaluated live-virus n...

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Main Authors: Stich, Maximilian (Author) , Benning, Louise (Author) , Speer, Claudius (Author) , Garbade, Sven (Author) , Bartenschlager, Marie (Author) , Kim, Heeyoung (Author) , Jeltsch, Kathrin (Author) , Tabatabai, Julia (Author) , Niesert, Moritz (Author) , Janda, Aleš (Author) , Renk, Hanna (Author) , Elling, Roland (Author) , Hoffmann, Georg F. (Author) , Kräusslich, Hans-Georg (Author) , Müller, Barbara (Author) , Bartenschlager, Ralf (Author) , Tönshoff, Burkhard (Author)
Format: Article (Journal)
Language:English
Published: 16 February 2023
In: Journal of medical virology
Year: 2023, Volume: 95, Issue: 3, Pages: 1-11
ISSN:1096-9071
DOI:10.1002/jmv.28582
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1002/jmv.28582
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.28582
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Author Notes:Maximilian Stich, Louise Benning, Claudius Speer, Sven F. Garbade, Marie Bartenschlager, Heeyoung Kim, Kathrin Jeltsch, Julia Tabatabai, Moritz Niesert, Aleš Janda, Hanna Renk, Roland Elling, Georg Friedrich Hoffmann, Hans-Georg Kräusslich, Barbara Müller, Ralf Bartenschlager, Burkhard Tönshoff
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Summary:Data on cross-neutralization of the SARS-CoV-2 omicron variant more than 1 year after SARS-CoV-2 infection are urgently needed, especially in children, to predict the likelihood of reinfection and to guide vaccination strategies. In a prospective observational cohort study, we evaluated live-virus neutralization of the SARS-CoV-2 omicron (BA.1) variant in children compared with adults 14 months after mild or asymptomatic wild-type SARS-CoV-2 infection. We also evaluated immunity to reinfection conferred by previous infection plus COVID-19 mRNA vaccination. We studied 36 adults and 34 children 14 months after acute SARS-CoV-2 infection. While 94% of unvaccinated adults (16/17) and children (32/34) neutralized the delta (B.1.617.2) variant, only 1/17 (5.9%) unvaccinated adults, 0/16 (0%) adolescents and 5/18 (27.8%) children <12 years of age had neutralizing activity against omicron (BA.1). In convalescent adults, one or two doses of mRNA vaccine increased delta and omicron neutralization 32-fold, similar to a third mRNA vaccination in uninfected adults. Neutralization of omicron was 8-fold lower than that of delta in both groups. In conclusion, our data indicate that humoral immunity induced by previous SARS-CoV-2 wild-type infection more than 1 year ago is insufficient to neutralize the current immune escape omicron variant.
Item Description:Gesehen am 22.05.2023
Physical Description:Online Resource
ISSN:1096-9071
DOI:10.1002/jmv.28582

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