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Extracellular vesicle-associated tyrosine kinase-like orphan receptors ROR1 and ROR2 promote breast cancer progression

Extracellular vesicles (EVs) harbor a plethora of different biomolecules, which they can transport across cells. In cancer, tumor-derived EVs thereby support the creation of a favorable tumor microenvironment. So far, EV uptake and cargo delivery into target cells have been regarded as the main mech...

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Main Authors: Irmer, Barnabas (Author) , Efing, Janes (Author) , Reitnauer, Lea (Author) , Angenendt, Allegra (Author) , Heinrichs, Saskia (Author) , Schubert, Antonia (Author) , Schulz, Matthias (Author) , Binder, Claudia (Author) , Tio, Joke (Author) , Hansen, Uwe (Author) , Geyer, Christiane (Author) , Gerwing, Mirjam (Author) , Bleckmann, Annalen (Author) , Menck, Kerstin (Author)
Format: Article (Journal)
Language:English
Published: 10 July 2023
In: Cell communication and signaling
Year: 2023, Volume: 21, Issue: 1, Pages: 1-19
ISSN:1478-811X
DOI:10.1186/s12964-023-01186-1
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12964-023-01186-1
Verlag, kostenfrei, Volltext: https://biosignaling.biomedcentral.com/articles/10.1186/s12964-023-01186-1
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Author Notes:Barnabas Irmer, Janes Efing, Lea Elisabeth Reitnauer, Allegra Angenendt, Saskia Heinrichs, Antonia Schubert, Matthias Schulz, Claudia Binder, Joke Tio, Uwe Hansen, Christiane Geyer, Mirjam Gerwing, Annalen Bleckman and Kerstin Menck
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Summary:Extracellular vesicles (EVs) harbor a plethora of different biomolecules, which they can transport across cells. In cancer, tumor-derived EVs thereby support the creation of a favorable tumor microenvironment. So far, EV uptake and cargo delivery into target cells have been regarded as the main mechanisms for the pro-tumoral function of EVs. To test this hypothesis, we investigated the fate of the oncogenic transmembrane Wnt tyrosine kinase-like orphan receptor 1 and 2 (ROR1, ROR2) delivered via distinct EV subpopulations to breast cancer cells and aimed to unravel their impact on tumor progression.
Item Description:Gesehen am 28.11.2023
Physical Description:Online Resource
ISSN:1478-811X
DOI:10.1186/s12964-023-01186-1

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