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Extracellular vesicle-associated tyrosine kinase-like orphan receptors ROR1 and ROR2 promote breast cancer progression

Extracellular vesicles (EVs) harbor a plethora of different biomolecules, which they can transport across cells. In cancer, tumor-derived EVs thereby support the creation of a favorable tumor microenvironment. So far, EV uptake and cargo delivery into target cells have been regarded as the main mech...

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Hauptverfasser: Irmer, Barnabas (VerfasserIn) , Efing, Janes (VerfasserIn) , Reitnauer, Lea (VerfasserIn) , Angenendt, Allegra (VerfasserIn) , Heinrichs, Saskia (VerfasserIn) , Schubert, Antonia (VerfasserIn) , Schulz, Matthias (VerfasserIn) , Binder, Claudia (VerfasserIn) , Tio, Joke (VerfasserIn) , Hansen, Uwe (VerfasserIn) , Geyer, Christiane (VerfasserIn) , Gerwing, Mirjam (VerfasserIn) , Bleckmann, Annalen (VerfasserIn) , Menck, Kerstin (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 10 July 2023
In: Cell communication and signaling
Year: 2023, Jahrgang: 21, Heft: 1, Pages: 1-19
ISSN:1478-811X
DOI:10.1186/s12964-023-01186-1
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12964-023-01186-1
Verlag, kostenfrei, Volltext: https://biosignaling.biomedcentral.com/articles/10.1186/s12964-023-01186-1
Volltext
Verfasserangaben:Barnabas Irmer, Janes Efing, Lea Elisabeth Reitnauer, Allegra Angenendt, Saskia Heinrichs, Antonia Schubert, Matthias Schulz, Claudia Binder, Joke Tio, Uwe Hansen, Christiane Geyer, Mirjam Gerwing, Annalen Bleckman and Kerstin Menck
Beschreibung
Zusammenfassung:Extracellular vesicles (EVs) harbor a plethora of different biomolecules, which they can transport across cells. In cancer, tumor-derived EVs thereby support the creation of a favorable tumor microenvironment. So far, EV uptake and cargo delivery into target cells have been regarded as the main mechanisms for the pro-tumoral function of EVs. To test this hypothesis, we investigated the fate of the oncogenic transmembrane Wnt tyrosine kinase-like orphan receptor 1 and 2 (ROR1, ROR2) delivered via distinct EV subpopulations to breast cancer cells and aimed to unravel their impact on tumor progression.
Beschreibung:Gesehen am 28.11.2023
Beschreibung:Online Resource
ISSN:1478-811X
DOI:10.1186/s12964-023-01186-1

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